Luger Thomas, Seite Sophie, Humbert Philippe, Krutmann Jean, Triller Raoul, Dréno Brigitte
Department of Dermatology, University of Muenster, Muenster, Germany.
La Roche-Posay Laboratoire Pharmaceutique, 110 Avenue Henri Barbusse, 92602 Asnieres Cedex, France.
Eur J Dermatol. 2014 Mar-Apr;24(2):194-200. doi: 10.1684/ejd.2014.2294.
Psoriasis is a multifactorial disease involving both genetic predisposition and external triggers, resulting in epidermal and immune dysfunctions. Regardless of the severity of the disease, patients require additional basic topical treatment with emollients. Basic skin care products are well known for their role in moisture retention and symptom control in psoriasis, yet patients underuse them. Dry skin and cutaneous inflammation are associated with an impaired epidermal barrier function. This breakdown of the skin barrier causes the release of pro-inflammatory mediators that exaggerate inflammation.
to provide recommendations for the use of emollients (including ceramides, urea, keratolytic agents, zinc salts, niacinamide), thermal water and skin care products in psoriasis.
A review of the current literature from 2000 to 2012 using Medline and Ovid was performed by a working group of five European Dermatologists with clinical and research experience in psoriasis.
Either alone or used adjunctively, basic topical therapy can restore and protect skin barrier function, increase remission times between flare-ups and enhance the effects of pharmaceutical therapy.
We provide physicians with a tool to assist them in implementing basic skin care in an integrated disease management approach.
银屑病是一种多因素疾病，涉及遗传易感性和外部触发因素，导致表皮和免疫功能障碍。无论疾病严重程度如何，患者都需要使用润肤剂进行额外的基础局部治疗。基础护肤品因其在银屑病保湿和症状控制方面的作用而广为人知，但患者对其使用不足。皮肤干燥和皮肤炎症与表皮屏障功能受损有关。皮肤屏障的这种破坏会导致促炎介质的释放，从而加剧炎症。
为银屑病患者使用润肤剂（包括神经酰胺、尿素、角质溶解剂、锌盐、烟酰胺）、温泉水和护肤品提供建议。
由五位在银屑病临床和研究方面有经验的欧洲皮肤科医生组成的工作组，对2000年至2012年的现有文献进行了检索，检索数据库为Medline和Ovid。
基础局部治疗单独使用或辅助使用时，均可恢复和保护皮肤屏障功能，延长发作间期的缓解时间，并增强药物治疗效果。
我们为医生提供了一种工具，以帮助他们在综合疾病管理方法中实施基础皮肤护理。
