Galderma Laboratories LP, Fort Worth, Texas.
Galderma Laboratories LP, Fort Worth, Texas.
J Am Acad Dermatol. 2014 Jul;71(1):177-84. doi: 10.1016/j.jaad.2014.01.891. Epub 2014 Mar 20.
Ceramides (CERs) are epidermal lipids that are important for skin barrier function. Much research has been devoted to identifying the numerous CERs found in human skin and their function. Alterations in CER content are associated with a number of skin diseases such as atopic dermatitis. Newer formulations of skin-care products have incorporated CERs into their formulations with the goal of exogenously applying CERs to help skin barrier function. CERs are a complex class of molecules and because of their growing ubiquity in skin-care products, a clear understanding of their role in skin and use in skin-care products is essential for clinicians treating patients with skin diseases. This review provides an overview of the structure, function, and importance of skin CERs in diseased skin and how CERs are being used in skin-care products to improve or restore skin barrier function.
神经酰胺是表皮脂质的一种，对于皮肤屏障功能十分重要。大量研究致力于鉴定人体皮肤中发现的多种神经酰胺及其功能。神经酰胺含量的改变与许多皮肤疾病有关，如特应性皮炎。新型护肤品配方将神经酰胺纳入其配方中，旨在通过外源性应用神经酰胺来帮助改善皮肤屏障功能。神经酰胺是一类复杂的分子，由于其在护肤品中日益普及，因此对于皮肤科医生治疗皮肤病患者而言，了解其在皮肤中的作用以及在护肤品中的应用至关重要。本文综述了皮肤神经酰胺的结构、功能以及在疾病皮肤中的重要性，以及神经酰胺如何用于护肤品以改善或恢复皮肤屏障功能。
