Palmer Biff F
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
Clin J Am Soc Nephrol. 2015 Jun 5;10(6):1050-60. doi: 10.2215/CJN.08580813. Epub 2014 Apr 10.
Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper distribution of potassium across the cell membrane is critical for normal cell function. Long-term maintenance of potassium homeostasis is achieved by alterations in renal excretion of potassium in response to variations in intake. Understanding the mechanism and regulatory influences governing the internal distribution and renal clearance of potassium under normal circumstances can provide a framework for approaching disorders of potassium commonly encountered in clinical practice. This paper reviews key aspects of the normal regulation of potassium metabolism and is designed to serve as a readily accessible review for the well informed clinician as well as a resource for teaching trainees and medical students.
钾是细胞内液中含量最丰富的阳离子，维持钾在细胞膜两侧的适当分布对于正常细胞功能至关重要。通过根据摄入量的变化改变肾脏对钾的排泄，可实现钾稳态的长期维持。了解正常情况下钾的内部分布和肾脏清除的机制及调节影响，可为处理临床实践中常见的钾紊乱提供一个框架。本文综述了钾代谢正常调节的关键方面，旨在为知识渊博的临床医生提供一份易于获取的综述，同时作为培训学员和医学生的教学资源。
