Nowak J, Wiekhorst F, Trahms L, Odenbach S
Chair of Magnetofluiddynamics, Measuring and Automation Technology, Technische Universität Dresden, 01069 Dresden, Germany.
J Phys Condens Matter. 2014 Apr 30;26(17):176004. doi: 10.1088/0953-8984/26/17/176004. Epub 2014 Apr 11.
Suspensions of magnetic nanoparticles have received increasing interest in the biomedical field. While these ferrofluids are already used for magnetic resonance imaging, emerging research on cancer treatment focuses, for example, on employing the particles as drug carriers, or using them in magnetic hyperthermia to destroy diseased cells by heating of the particles. To enable safe and effective applications, an understanding of the flow behaviour of the ferrofluids is essential. Regarding the applications mentioned above, in which flow phenomena play an important role, viscosity under the influence of an external magnetic field is of special interest. In this respect, the magnetoviscous effect (MVE) leading to an increasing viscosity if an external magnetic field of a certain strength is applied, is well-known for singlecore ferrofluids used in the engineering context. In the biomedical context, multicore ferrofluids are preferred in order to avoid remanence magnetization and to enable a deposition of the particles by the organism without complications. This study focuses on a comparison of the MVE for three ferrofluids whose composition is identical except in relation to their hydrodynamic diameter and core composition-one of the fluids contains singlecore particles, while the other two feature multicore particles. This enables confident conclusions about the influence of those parameters on flow behaviour under the influence of a magnetic field. The strong effects found for two of the fluids should be taken into account, both in future investigations and in the potential use of such ferrofluids, as well as in manufacturing, in relation to the optimization of flow behaviour.
磁性纳米颗粒悬浮液在生物医学领域越来越受到关注。虽然这些铁磁流体已用于磁共振成像,但关于癌症治疗的新兴研究重点,例如,将这些颗粒用作药物载体,或在磁热疗中通过加热颗粒来破坏病变细胞。为了实现安全有效的应用,了解铁磁流体的流动行为至关重要。对于上述流动现象起重要作用的应用,外部磁场影响下的粘度特别令人感兴趣。在这方面,对于工程领域中使用的单核铁磁流体,施加一定强度的外部磁场会导致粘度增加的磁粘性效应(MVE)是众所周知的。在生物医学领域,为了避免剩磁并使生物体能够无并发症地沉积颗粒,多核铁磁流体更受青睐。本研究重点比较了三种铁磁流体的磁粘性效应,这三种铁磁流体的成分相同,只是流体动力学直径和核心组成不同——其中一种流体包含单核颗粒,而另外两种具有多核颗粒。这使得能够确定这些参数对磁场影响下流动行为的影响。在未来的研究以及此类铁磁流体的潜在应用中,以及在制造过程中,为了优化流动行为,都应考虑到在两种流体中发现的强烈影响。