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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Ash S A, Griffin G E

Department of Communicable Diseases, St George's Hospital Medical School, London.

Clin Sci (Lond). 1989 Jun;76(6):659-66. doi: 10.1042/cs0760659.

Intravenous infusion of endotoxin into rats over 18 h caused a reduction in food intake to 20% of normal levels, weight loss, hypoalbuminaemia and a fall in rates of protein synthesis in vivo in heart and skeletal muscle. 2. Measurements of protein turnover in vitro in skeletal muscle of endotoxaemic animals, showed a 50% fall in protein synthesis rates and a 200% increase in rates of protein degradation. 3. Total parenteral nutrition was only partially able to reverse endotoxin-induced weight loss. Total parenteral nutrition did not reverse endotoxin-induced catabolism in cardiac or skeletal muscle, but was able to reverse the catabolism of protein in skeletal muscle produced by starvation. 4. Endotoxin treatment elevated rates of protein synthesis in vivo in liver. The combination of parenteral nutrition and endotoxaemia further increased the rate of protein synthesis in the liver. Parenteral nutrition did not influence endotoxin-induced hypoalbuminaemia.

给大鼠静脉输注内毒素18小时以上，导致食物摄入量降至正常水平的20%，体重减轻，低白蛋白血症，以及心脏和骨骼肌体内蛋白质合成速率下降。2. 对内毒素血症动物骨骼肌的体外蛋白质周转测量显示，蛋白质合成速率下降50%，蛋白质降解速率增加200%。3. 全胃肠外营养仅部分能够逆转内毒素诱导的体重减轻。全胃肠外营养不能逆转内毒素诱导的心脏或骨骼肌分解代谢，但能够逆转饥饿引起的骨骼肌蛋白质分解代谢。4. 内毒素治疗提高了肝脏体内蛋白质合成速率。胃肠外营养和内毒素血症的联合进一步增加了肝脏蛋白质合成速率。胃肠外营养不影响内毒素诱导的低白蛋白血症。

Ash S A, Griffin G E

Department of Communicable Diseases, St George's Hospital Medical School, London.

Clin Sci (Lond). 1989 Jun;76(6):659-66. doi: 10.1042/cs0760659.

Intravenous infusion of endotoxin into rats over 18 h caused a reduction in food intake to 20% of normal levels, weight loss, hypoalbuminaemia and a fall in rates of protein synthesis in vivo in heart and skeletal muscle. 2. Measurements of protein turnover in vitro in skeletal muscle of endotoxaemic animals, showed a 50% fall in protein synthesis rates and a 200% increase in rates of protein degradation. 3. Total parenteral nutrition was only partially able to reverse endotoxin-induced weight loss. Total parenteral nutrition did not reverse endotoxin-induced catabolism in cardiac or skeletal muscle, but was able to reverse the catabolism of protein in skeletal muscle produced by starvation. 4. Endotoxin treatment elevated rates of protein synthesis in vivo in liver. The combination of parenteral nutrition and endotoxaemia further increased the rate of protein synthesis in the liver. Parenteral nutrition did not influence endotoxin-induced hypoalbuminaemia.

给大鼠静脉输注内毒素18小时以上，导致食物摄入量降至正常水平的20%，体重减轻，低白蛋白血症，以及心脏和骨骼肌体内蛋白质合成速率下降。2. 对内毒素血症动物骨骼肌的体外蛋白质周转测量显示，蛋白质合成速率下降50%，蛋白质降解速率增加200%。3. 全胃肠外营养仅部分能够逆转内毒素诱导的体重减轻。全胃肠外营养不能逆转内毒素诱导的心脏或骨骼肌分解代谢，但能够逆转饥饿引起的骨骼肌蛋白质分解代谢。4. 内毒素治疗提高了肝脏体内蛋白质合成速率。胃肠外营养和内毒素血症的联合进一步增加了肝脏蛋白质合成速率。胃肠外营养不影响内毒素诱导的低白蛋白血症。