Department of Neurosurgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, PR China.
Department of Oncology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, PR China.
Biomed Pharmacother. 2021 Feb;134:111115. doi: 10.1016/j.biopha.2020.111115. Epub 2020 Dec 16.
Glioblastoma (GBM) is the most common primary malignant tumor in adults, and its morbidity and mortality are very high. Although progress has been achieved in the treatment of GBM, such as surgery, chemotherapy and radiotherapy, in recent years, the prognosis of patients with GBM has not improved significantly. MicroRNAs (miRNAs) are endogenous noncoding single-stranded RNAs consisting of approximately 20-22 nucleotides that regulate gene expression at the posttranscriptional level by binding to target protein-encoding mRNAs. Notably, miRNAs regulate various carcinogenic pathways, one of which is the epidermal growth factor receptor (EGFR) signaling pathway, which controls cell proliferation, invasion, migration, angiogenesis and apoptosis. In this review, we summarize the novel discoveries of roles for miRNAs targeting the factors in the EGFR signaling pathway in the occurrence and development of GBM. In addition, we describe their potential roles as biomarkers for the diagnosis and prognosis of GBM and for determining the treatment resistance of GBM and the efficacy of therapeutic drugs.
胶质母细胞瘤（GBM）是成人中最常见的原发性恶性肿瘤，其发病率和死亡率都非常高。尽管近年来在 GBM 的治疗方面取得了进展，如手术、化疗和放疗，但 GBM 患者的预后并没有显著改善。微小 RNA（miRNA）是由大约 20-22 个核苷酸组成的内源性非编码单链 RNA，通过与靶蛋白编码 mRNAs 结合在转录后水平调节基因表达。值得注意的是，miRNA 调节各种致癌途径，其中之一是表皮生长因子受体（EGFR）信号通路，它控制细胞增殖、侵袭、迁移、血管生成和凋亡。在这篇综述中，我们总结了 miRNA 靶向 EGFR 信号通路因子在 GBM 发生和发展中的新作用的发现。此外，我们描述了它们作为 GBM 诊断和预后标志物的潜在作用，以及确定 GBM 治疗耐药性和治疗药物疗效的作用。
