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雄激素依赖的大鼠前列腺蛋白，前列腺素，是一种与肝素结合生长因子-1共同纯化的肝素结合蛋白。

The androgen-dependent rat prostate protein, probasin, is a heparin-binding protein that co-purifies with heparin-binding growth factor-1.

作者信息

Matuo Y, Adams P S, Nishi N, Yasumitsu H, Crabb J W, Matusik R J, McKeehan W L

机构信息

Department of Endocrinology, Kagawa Medical School, 1750, Japan.

出版信息

In Vitro Cell Dev Biol. 1989 Jun;25(6):581-4. doi: 10.1007/BF02623572.

DOI:10.1007/BF02623572
PMID:2472375
Abstract

Rat prostate extracts contain an abundant 20-22 kilodalton heparin-binding protein with near identical chromatographic properties, but only 0.2-1% of the mitogenic activity, of bovine brain heparin-binding growth factor-1 (acidic fibroblast growth factor). Amino terminal amino acid sequence (met-met-thr-asp-lys-asn-leu-lys-lys-lys-ile-glu-gly-asn-trp-arg-thr-val -tyr- leu-ala-ala-ser-?-val-glu-lys-ile-asn-glu-gly-ser-pro) and immunochemical analysis revealed that the protein is identical to the androgen-dependent protein "probasin".

摘要

大鼠前列腺提取物含有一种丰富的20 - 22千道尔顿的肝素结合蛋白，其色谱特性与牛脑肝素结合生长因子-1（酸性成纤维细胞生长因子）几乎相同，但促有丝分裂活性仅为其0.2 - 1%。氨基末端氨基酸序列（甲硫氨酸-甲硫氨酸-苏氨酸-天冬氨酸-赖氨酸-天冬酰胺-亮氨酸-赖氨酸-赖氨酸-赖氨酸-异亮氨酸-谷氨酸-甘氨酸-天冬酰胺-色氨酸-精氨酸-苏氨酸-缬氨酸-酪氨酸-亮氨酸-丙氨酸-丙氨酸-丝氨酸-？-缬氨酸-谷氨酸-赖氨酸-异亮氨酸-天冬酰胺-谷氨酸-甘氨酸-丝氨酸-脯氨酸）和免疫化学分析表明，该蛋白与雄激素依赖性蛋白“前B细胞集落增强因子”相同。

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The androgen-dependent rat prostate protein, probasin, is a heparin-binding protein that co-purifies with heparin-binding growth factor-1.雄激素依赖的大鼠前列腺蛋白，前列腺素，是一种与肝素结合生长因子-1共同纯化的肝素结合蛋白。
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本文引用的文献

1
Isolation and characterization of androgen-dependent non-histone chromosomal protein from dorsolateral prostate of rats.从大鼠背外侧前列腺中分离和鉴定雄激素依赖性非组蛋白染色体蛋白。
Biochem Biophys Res Commun. 1982 Nov 30;109(2):334-40. doi: 10.1016/0006-291x(82)91725-9.
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Changes of an androgen-dependent nuclear protein during functional differentiation and by dedifferentiation of the dorsolateral prostate of rats.
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Lobe-specific distribution of a 20,000-dalton nonhistone protein in the dorsolateral prostate of rats.大鼠背外侧前列腺中一种20,000道尔顿非组蛋白的叶特异性分布。
体内自发永生化祖细胞和中间细胞对良性人前列腺组织的功能重塑。
Stem Cells. 2010 Feb;28(2):344-56. doi: 10.1002/stem.284.
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Localization of prostatic basic protein ("probasin") in the rat prostates by use of monoclonal antibody.利用单克隆抗体对大鼠前列腺中前列腺碱性蛋白（“前列腺素”）进行定位。
Biochem Biophys Res Commun. 1985 Jul 16;130(1):293-300. doi: 10.1016/0006-291x(85)90416-4.
5
Heparin binding affinity of rat prostatic growth factor in normal and cancerous prostates: partial purification and characterization of rat prostatic growth factor in the Dunning tumor.正常及癌性前列腺组织中大鼠前列腺生长因子的肝素结合亲和力：Dunning肿瘤中大鼠前列腺生长因子的部分纯化及特性鉴定
Cancer Res. 1987 Jan 1;47(1):188-92.
6
Complete primary structure of prostatropin, a prostate epithelial cell growth factor.前列腺促生长素（一种前列腺上皮细胞生长因子）的完整一级结构。
Biochemistry. 1986 Sep 9;25(18):4988-93. doi: 10.1021/bi00366a003.
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Sequence analysis, cellular localization, and expression of a neuroretina adhesion and cell survival molecule.一种神经视网膜黏附及细胞存活分子的序列分析、细胞定位与表达
Cell. 1987 Oct 9;51(1):135-42. doi: 10.1016/0092-8674(87)90018-3.
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Different hormonal requirements for androgen-independent growth of normal and tumor epithelial cells from rat prostate.
In Vitro Cell Dev Biol. 1987 Feb;23(2):147-52. doi: 10.1007/BF02623596.
9
Stabilization of fibroblast growth factors by a non-cytotoxic zwitterionic detergent, 3-[(3-cholamidopropyl)dimethylammonio]-1-propane sulfonate (CHAPS).通过一种无细胞毒性的两性离子去污剂3-[(3-胆酰胺丙基)二甲基铵]-1-丙烷磺酸盐（CHAPS）对成纤维细胞生长因子进行稳定化处理。
In Vitro Cell Dev Biol. 1988 May;24(5):477-80. doi: 10.1007/BF02628502.
10
Heparin-binding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors.
Cancer Res. 1989 May 1;49(9):2485-94.