Dauvermann Maria R, Whalley Heather C, Schmidt André, Lee Graham L, Romaniuk Liana, Roberts Neil, Johnstone Eve C, Lawrie Stephen M, Moorhead Thomas W J
Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh , Edinburgh , UK.
Department of Psychiatry, University of Basel , Basel , Switzerland ; Medical Image Analysis Center, University Hospital Basel , Basel , Switzerland.
Front Psychiatry. 2014 Mar 25;5:30. doi: 10.3389/fpsyt.2014.00030. eCollection 2014.
Computational modeling of functional brain networks in fMRI data has advanced the understanding of higher cognitive function. It is hypothesized that functional networks mediating higher cognitive processes are disrupted in people with schizophrenia. In this article, we review studies that applied measures of functional and effective connectivity to fMRI data during cognitive tasks, in particular working memory fMRI studies. We provide a conceptual summary of the main findings in fMRI data and their relationship with neurotransmitter systems, which are known to be altered in individuals with schizophrenia. We consider possible developments in computational neuropsychiatry, which are likely to further our understanding of how key functional networks are altered in schizophrenia.
功能磁共振成像（fMRI）数据中功能性脑网络的计算建模推动了对高级认知功能的理解。据推测，介导高级认知过程的功能网络在精神分裂症患者中会受到破坏。在本文中，我们回顾了在认知任务期间将功能连接和有效连接测量方法应用于fMRI数据的研究，特别是工作记忆fMRI研究。我们对fMRI数据中的主要发现及其与神经递质系统的关系进行了概念性总结，已知神经递质系统在精神分裂症患者中会发生改变。我们考虑了计算神经精神病学可能的发展，这可能会进一步加深我们对精神分裂症中关键功能网络如何改变的理解。
