Department of Radiology, Wake Forest University School of Medicine Winston-Salem, NC, USA.
Department of Radiology, Wake Forest University School of Medicine Winston-Salem, NC, USA ; Translational Science Center, Wake Forest University Winston-Salem, NC, USA.
Front Psychol. 2014 Mar 25;5:249. doi: 10.3389/fpsyg.2014.00249. eCollection 2014.
There is a growing awareness in the field of neuroscience that the self-regulation of eating behavior is driven by complex networks within the brain. These networks may be vulnerable to "hot states" which people can move into and out of dynamically throughout the course of a day as a function of changes in affect or visceral cues. The goal of the current study was to identify and determine differences in the Hot-state Brain Network of Appetite (HBN-A) that exists after a brief period of food restraint followed either by the consumption of a meal replacement (MR) or water. Fourteen overweight/obese adults came to our laboratory on two different occasions. Both times they consumed a controlled breakfast meal and then were restricted from eating for 2.5 h prior to an MRI scan. On one visit, they consumed a meal replacement (MR) liquid meal after this period of food restriction; on the other visit they consumed an equal amount of water. After these manipulations, the participants underwent a resting fMRI scan. Our first study aim employed an exploratory, data-driven approach to identify hubs relevant to the HBN-A. Using data from the water condition, five regions were found to be the hubs or nodes of the HBN-A: insula, anterior cingulated cortex, the superior temporal pole, the amygdala, and the hippocampus. We then demonstrated that the consumption of a liquid MR dampened interconnectivity between the nodes of the HBN-A as compared to water. Importantly and consistent with these network data, the consumption of a MR beverage also lowered state cravings and hunger.
神经科学领域越来越意识到，饮食行为的自我调节是由大脑内部的复杂网络驱动的。这些网络可能容易受到“热点状态”的影响，人们可以在一天中动态地进入和离开这些状态，这是情绪或内脏线索变化的结果。本研究的目的是确定并确定在短暂的食物限制后存在的食欲热点状态大脑网络（HBN-A）的差异，这些差异在摄入替代餐（MR）或水后存在。14 名超重/肥胖成年人在两次不同的时间来到我们的实验室。两次他们都吃了一顿控制早餐，然后在 MRI 扫描前被限制进食 2.5 小时。在一次访问中，他们在这段时间的食物限制后摄入了替代餐（MR）液体餐；在另一次访问中，他们摄入了等量的水。在这些操作之后，参与者进行了休息 fMRI 扫描。我们的第一个研究目的采用了探索性的、数据驱动的方法来确定与 HBN-A 相关的枢纽。使用水条件的数据，发现五个区域是 HBN-A 的枢纽或节点：脑岛、前扣带皮层、颞上极、杏仁核和海马体。然后我们证明，与水相比，液体 MR 的消耗降低了 HBN-A 节点之间的连通性。重要的是，与这些网络数据一致，MR 饮料的摄入也降低了状态性渴望和饥饿感。
