Van Overmeire Eva, Laoui Damya, Keirsse Jiri, Van Ginderachter Jo A, Sarukhan Adelaida
Myeloid Cell Immunology Laboratory, VIB , Brussels , Belgium ; Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel , Brussels , Belgium.
Myeloid Cell Immunology Laboratory, VIB , Brussels , Belgium ; Lab of Cellular and Molecular Immunology, Vrije Universiteit Brussel , Brussels , Belgium ; Institut national de la santé et de la recherche médicale , Paris , France.
Front Immunol. 2014 Mar 26;5:127. doi: 10.3389/fimmu.2014.00127. eCollection 2014.
Macrophages are extremely versatile cells that adopt a distinct phenotype in response to a changing microenvironment. Consequently, macrophages are involved in diverse functions, ranging from organogenesis and tissue homeostasis to recognition and destruction of invading pathogens. In cancer, tumor-associated macrophages (TAM) often contribute to tumor progression by increasing cancer cell migration and invasiveness, stimulating angiogenesis, and suppressing anti-tumor immunity. Accumulating evidence suggests that these different functions could be exerted by specialized TAM subpopulations. Here, we discuss the potential underlying mechanisms regulating TAM specialization and elaborate on TAM heterogeneity in terms of their ontogeny, activation state, and intra-tumoral localization. In addition, parallels are drawn between TAM and macrophages in other tissues. Together, a better understanding of TAM diversity could provide a rationale for novel strategies aimed at targeting the most potent tumor-supporting macrophages.
巨噬细胞是极具多能性的细胞，会根据不断变化的微环境呈现出不同的表型。因此，巨噬细胞参与多种功能，从器官发生和组织稳态到识别和破坏入侵病原体。在癌症中，肿瘤相关巨噬细胞（TAM）通常通过增加癌细胞迁移和侵袭性、刺激血管生成以及抑制抗肿瘤免疫来促进肿瘤进展。越来越多的证据表明，这些不同功能可能由特定的TAM亚群发挥。在此，我们讨论调节TAM特化的潜在机制，并从其个体发育、激活状态和肿瘤内定位方面阐述TAM的异质性。此外，还比较了TAM与其他组织中的巨噬细胞。总之，更好地理解TAM的多样性可为旨在靶向最具肿瘤支持作用的巨噬细胞的新策略提供理论依据。
