1. Orenburg State Medical Academy, Orenburg, Russia.
2. Institute of Experimental Diagnostics and Therapy of Tumors, Russian Oncological Scientific Center named after N.N.Blokhin, Moscow, Russia.
J Cancer. 2014 Mar 20;5(5):311-9. doi: 10.7150/jca.8716. eCollection 2014.
The "cavitary" type of angiogenesis in patients with gastric cancer (GC) is described for the first time.
The samples of tumour and adjacent gastric mucosa (GM) in 73 patients with GC who had undergone radical surgery were being studied. The sections were stained with hematoxylin and eosin (H&E) and immunohistochemically (IGH) using antibodies to CD34.
А new type of vessel formation consists of the appearance of cavitary structures (CS) in tumours and the adjacent GM, which are then lined by endothelial cells and merged into the blood vessels of the organ. We believe that the CS can be formed by means: 1) of the abruption of layers of epithelial cells (both normal and tumoral) from their underlying foundation and their desquamation into the lumen of the "obliterated" gastric glands (GG); 2) of the dilatation of the GG and thinning of their walls; 3) of the formation of "cavity" directly in the lamina propria of GM or in the tumoral stroma. It was noted that only the presence of multiple "cavitary" vessels (CV) of type-1 had been associated with the decrease of 3-year overall survival (OR=15,0, 95%CI=2,96-76,31) and relapse-free survival (OR=14,93, 95%CI=4,34-51,38). We also observed the improvement of the long-term outcomes in patients with GC having received antibacterial therapy (AT) before surgery that can be associated with its influence on the formation of CV type-1.
The described new type of angiogenesis is of great clinical importance.
首次描述了胃癌（GC）患者的“腔隙状”血管生成类型。
对 73 例接受根治性手术的 GC 患者的肿瘤和相邻胃黏膜（GM）样本进行了研究。使用针对 CD34 的抗体对组织进行苏木精和伊红（H＆E）和免疫组织化学（IGH）染色。
一种新的血管生成类型包括肿瘤和相邻 GM 中腔隙状结构（CS）的出现，然后由内皮细胞排列并融合到器官的血管中。我们认为 CS 可以通过以下方式形成：1）上皮细胞（正常和肿瘤）的层从其基础层中断裂并脱落到“闭塞”胃腺（GG）的管腔中；2）GG 的扩张和壁变薄；3）在 GM 的固有层或肿瘤基质中直接形成“腔”。值得注意的是，只有存在多种 1 型“腔隙”血管（CV）才与 3 年总生存率（OR=15.0，95%CI=2.96-76.31）和无复发生存率（OR=14.93，95%CI=4.34-51.38）降低相关。我们还观察到接受手术前抗菌治疗（AT）的 GC 患者的长期预后得到改善，这可能与其对 CV 1 型形成的影响有关。
所描述的新型血管生成具有重要的临床意义。
