Gynecologic and Breast Research Laboratory, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC, USA, and Jilin University, China.
J Cancer. 2010 Jun 2;1:32-7. doi: 10.7150/jca.1.32.
Human breast cancer represents a group of highly heterogeneous lesions consisting of about 20 morphologically and immnohistochemically distinct subtypes with substantially different prognoses. Our recent studies have suggested that all breast cancer subtypes, however, may share a common pathway, tumor cell budding from focally disrupted tumor capsules, for their invasion. The potential mechanisms and clinical implications of our observations are discussed.
人类乳腺癌是一组高度异质的病变，包括约 20 种形态和免疫组织化学上不同的亚型，其预后有很大的不同。我们最近的研究表明，所有乳腺癌亚型可能都有一个共同的途径，即肿瘤细胞从局部破坏的肿瘤包膜中芽生，从而发生侵袭。讨论了我们观察结果的潜在机制和临床意义。
