Chung Tae-Heum, Kim Moon-Chan, Kim Chang-Sup
Department of Family Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Korean J Fam Med. 2014 Mar;35(2):81-9. doi: 10.4082/kjfm.2014.35.2.81. Epub 2014 Mar 24.
Infection with hepatitis B virus (HBV) may be a risk factor for cardiovascular disease. We investigated the relationship between HBV infection and metabolic syndrome.
We performed a cross-sectional study of 9,474 Korean men and women who were at least 20 years old and who underwent a routine health check-up at Ulsan University Hospital in Ulsan, South Korea between March 2008 and February 2009. The associations of hepatitis B surface antigen (HBsAg) seropositivity with the presence of metabolic syndrome and its components were investigated by logistic regression analysis. Data were analyzed separately for males and females.
HBsAg seropositivity was significantly negatively associated with hypertriglyceridemia and metabolic syndrome in men (odds ratio [OR], 0.39; 95% confidence interval [CI], 0.29 to 0.50; P < 0.001 and OR, 0.75; 95% CI, 0.57 to 0.98, P = 0.033). In women, HBsAg seropositivity was also significantly negatively associated with hypertriglyceridemia, but not with metabolic syndrome (OR, 0.40; 95% CI, 0.17 to 0.91; P = 0.029 and OR, 0.80; 95% CI, 0.38 to 1.66, P = 0.545).
HBV infection was significantly negatively associated with hypertriglyceridemia and metabolic syndrome in men and hypertriglyceridemia in women.
感染乙型肝炎病毒（HBV）可能是心血管疾病的一个危险因素。我们调查了HBV感染与代谢综合征之间的关系。
我们对9474名年龄至少20岁、于2008年3月至2009年2月在韩国蔚山蔚山大学医院接受常规健康检查的韩国男性和女性进行了一项横断面研究。通过逻辑回归分析研究了乙肝表面抗原（HBsAg）血清学阳性与代谢综合征及其组分存在之间的关联。数据分别对男性和女性进行分析。
在男性中，HBsAg血清学阳性与高甘油三酯血症和代谢综合征显著负相关（比值比[OR]，0.39；95%置信区间[CI]，0.29至0.50；P<0.001以及OR，0.75；95%CI，0.57至0.98，P = 0.033）。在女性中，HBsAg血清学阳性也与高甘油三酯血症显著负相关，但与代谢综合征无关（OR，0.40；95%CI，0.17至0.91；P = 0.029以及OR，0.80；95%CI，0.38至1.66，P = 0.545）。
HBV感染与男性的高甘油三酯血症和代谢综合征以及女性的高甘油三酯血症显著负相关。
