Zhao Xiaohui, Shah Drishti, Sambamoorthi Usha
Department of Pharmaceutical Systems and Policy, School of Pharmacy, West Virginia University, 1 Medical Center Drive, PO Box 9510, Morgantown, WV 26506 USA.
J Diabetes Metab Disord. 2018 Oct 27;17(2):223-232. doi: 10.1007/s40200-018-0364-4. eCollection 2018 Dec.
The association between chronic hepatitis B (CHB) infection and metabolic syndrome (MetS) remains inconclusive. This study was designed to determine the association between CHB infection and MetS among the US population with updated data and adjustments for a comprehensive set of risk factors.
Adults aged 18 years or older who were clinically assessed for Hepatitis B and MetS from the National Health and Nutrition Examination Survey (NHANES) 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012, and 2013-2014 cycles were included in the study ( = 53,392,666). MetS was defined according to the NCEP/ATP III guideline. CHB was identified by the seropositivity of Hepatitis B surface antigen and core antibody in the absence of Hepatitis B surface antibody. Rao-Scott test and logistic regressions were employed in the analyses.
MetS was less prevalent among adults with CHB compared to adults without CHB (12.1% vs. 18.8%, = 0.073). In adjusted analyses, adults with CHB were 48% less likely to have MetS compared to those without CHB (95% Confidence Interval [CI]: 0.29-0.94). Regarding individual component of MetS, CHB was inversely associated with high waist circumference (AOR = 0.32, 95% CI: 0.21-0.49) and hypoalphalipoproteinemia (AOR = 0.48, 95% CI: 0.25-0.91). No association between CHB and other metabolic components were found.
CHB was inversely associated with MetS, high waist circumference, and hypoalphalipoproteinemia. No significant association was found between CHB and other MetS components.
慢性乙型肝炎（CHB）感染与代谢综合征（MetS）之间的关联尚无定论。本研究旨在利用更新的数据并对一系列综合风险因素进行调整，以确定美国人群中CHB感染与MetS之间的关联。
纳入2003 - 2004年、2005 - 2006年、2007 - 2008年、2009 - 2010年、2011 - 2012年以及2013 - 2014年周期的美国国家健康与营养检查调查（NHANES）中接受过乙肝和MetS临床评估的18岁及以上成年人（n = 53,392,666）。MetS根据美国国家胆固醇教育计划成人治疗组第三次报告（NCEP/ATP III）指南定义。CHB通过乙肝表面抗原和核心抗体血清阳性且无乙肝表面抗体来确定。分析采用Rao - Scott检验和逻辑回归。
与未感染CHB的成年人相比，感染CHB的成年人中MetS的患病率较低（12.1%对18.8%，P = 0.073）。在调整分析中，与未感染CHB的成年人相比，感染CHB的成年人患MetS的可能性低48%（95%置信区间[CI]：0.29 - 0.94）。关于MetS的各个组成部分，CHB与高腰围（调整后比值比[AOR] = 0.32，95% CI：0.21 - 0.49）和低α脂蛋白血症（AOR = 0.48，95% CI：0.25 - 0.91）呈负相关。未发现CHB与其他代谢成分之间存在关联。
CHB与MetS、高腰围和低α脂蛋白血症呈负相关。未发现CHB与其他MetS成分之间存在显著关联。
