Jougleux-Vie Caroline, Duhin Emeline, Deken Valerie, Outteryck Olivier, Vermersch Patrick, Zéphir Hélène
Department of Neurology, Roger Salengro Hospital, 59037 Lille, France.
Department of Biostatistics and INSERM EA 2694, Lille University Hospital and University of Lille North of France, 59037 Lille, France.
Mult Scler Int. 2014;2014:692468. doi: 10.1155/2014/692468. Epub 2014 Mar 2.
Background and Purpose. Fatigue and memory impairment are common symptoms in multiple sclerosis (MS) and both may interact with cognition. This can contribute to making a complaint misrepresentative of the objective disorder. We sought to determine whether fatigue complaint in MS reflects memory impairment and investigated whether patients' subjective fatigue is associated with memory complaint. Methods. Fifty MS patients complaining of fatigue underwent subjective assessment of fatigue and memory complaint measured using self-assessment scales. Cognitive functions were assessed using a battery of neuropsychological tests, including a test of verbal episodic memory, the selective reminding test (SRT). Correlations were studied between subjective fatigue, memory complaint, and performance in verbal episodic memory. Results. Depression score, psychotropic and/or antiepileptic drug use, Expanded Disability Status Scale (EDSS) score, and MS form were confounding factors. After adjusting for these confounding factors, neither fatigue complaint nor memory complaint was correlated with SRT performance. Subjective fatigue was significantly associated with memory complaint. Conclusion. Although complaint of fatigue in MS was correlated with memory complaint, subjective fatigue was not the expression of memory impairment.
背景与目的。疲劳和记忆障碍是多发性硬化症（MS）的常见症状，二者都可能与认知相互作用。这可能导致患者的主诉不能准确反映客观病症。我们试图确定MS患者的疲劳主诉是否反映记忆障碍，并研究患者的主观疲劳是否与记忆主诉相关。方法。50名主诉疲劳的MS患者接受了疲劳主观评估以及使用自评量表测量的记忆主诉评估。使用一系列神经心理学测试评估认知功能，包括言语情景记忆测试、选择性提醒测试（SRT）。研究主观疲劳、记忆主诉与言语情景记忆表现之间的相关性。结果。抑郁评分、使用精神药物和/或抗癫痫药物、扩展残疾状态量表（EDSS）评分以及MS类型均为混杂因素。在对这些混杂因素进行校正后，疲劳主诉和记忆主诉均与SRT表现无关。主观疲劳与记忆主诉显著相关。结论。虽然MS患者的疲劳主诉与记忆主诉相关，但主观疲劳并非记忆障碍的表现。
