前列腺素途径基因中的遗传多态性与头颈癌风险
Genetic polymorphisms in the prostaglandin pathway genes and risk of head and neck cancer.
作者信息
Lee W-T, Huang C-C, Chen K-C, Wong T-Y, Ou C-Y, Tsai S-T, Yen C-J, Fang S-Y, Lo H-I, Wu Y-H, Hsueh W-T, Yang M-W, Lin F-C, Hsiao J-R, Huang J-S, Chang J-Y, Chang K-Y, Wu S-Y, Lin C-L, Wang Y-H, Weng Y-L, Yang H-C, Chang J S
机构信息
Department of Otolaryngology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
出版信息
Oral Dis. 2015 Mar;21(2):207-15. doi: 10.1111/odi.12244. Epub 2014 Apr 28.
OBJECTIVE
Previous studies examining the association between genetic variations in prostaglandin pathway and risk of head and neck cancer (HNC) have only included polymorphisms in the PTGS2 (COX2) gene. This study investigated the association between genetic polymorphisms of six prostaglandin pathway genes (PGDS, PTGDS, PTGES, PTGIS, PTGS1 and PTGS2), and risk of HNC.
METHODS
Interviews regarding the consumption of alcohol, betel quid, and cigarette were conducted with 222 HNC cases and 214 controls. Genotyping was performed for 48 tag and functional single-nucleotide polymorphisms (SNPs).
RESULTS
Two tag SNPs of PTGIS showed a significant association with HNC risk [rs522962: log-additive odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.01-1.99 and dominant OR = 1.58, 95% CI: 1.02-2.47; rs6125671: log-additive OR = 1.49, 95% CI: 1.08-2.05 and dominant OR = 1.96, 95% CI: 1.16-3.32]. In addition, a region in PTGIS tagged by rs927068 and rs6019902 was significantly associated with risk of HNC (global P = 0.007). Finally, several SNPs interacted with betel quid and cigarette to influence the risk of HNC.
CONCLUSIONS
Genetic variations in prostaglandin pathway genes are associated with risk of HNC and may modify the relationship between use of betel quid or cigarette and development of HNC.
目的
以往研究前列腺素通路基因变异与头颈癌（HNC）风险之间的关联时，仅纳入了PTGS2（COX2）基因的多态性。本研究调查了六个前列腺素通路基因（PGDS、PTGDS、PTGES、PTGIS、PTGS1和PTGS2）的基因多态性与HNC风险之间的关联。
方法
对222例HNC病例和214例对照进行了关于饮酒、嚼槟榔和吸烟情况的访谈。对48个标签单核苷酸多态性（SNP）和功能性SNP进行基因分型。
结果
PTGIS的两个标签SNP与HNC风险显著相关[rs522962：对数相加比值比（OR）=1.42，95%置信区间（CI）：1.01-1.99，显性OR=1.58，95%CI：1.02-2.47；rs6125671：对数相加OR=1.49，95%CI：1.08-2.05，显性OR=1.96，95%CI：1.16-3.32]。此外，由rs927068和rs6019902标记的PTGIS区域与HNC风险显著相关（全局P=0.007）。最后，几个SNP与槟榔和香烟相互作用，影响HNC风险。
结论
前列腺素通路基因的遗传变异与HNC风险相关，并可能改变嚼槟榔或吸烟与HNC发生之间的关系。
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