Department of Gynecology and Obstetrics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong, China.
Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong, China.
Aging (Albany NY). 2020 May 28;12(10):9658-9685. doi: 10.18632/aging.103235.
Prostaglandin I2 synthase (PTGIS) is a crucial gene for the synthesis of prostaglandin I2, which has multiple roles in inflammation and immune modulation. However, studies on the prognostic value of PTGIS and its correlation with tumor-infiltrating immune cells in multiple cancers are still rare.
Multiple datasets of the Oncomine database showed that PTGIS was expressed at low levels in lung cancer and ovarian cancer compared to the levels in normal tissues. Kaplan-Meier plotter showed that high PTGIS was associated with poor overall survival and progression-free survival in lung, ovarian, and gastric cancers. Moreover, PTGIS expression was significantly positively correlated with infiltrating levels of macrophages and was strongly associated with a variety of immune markers, especially tumor-associated macrophages (TAMs) and T-regulatory cells (Tregs).
High expression of PTGIS could promote the infiltration of TAMs and Tregs in the tumor microenvironment and deteriorate outcomes of patients with lung, ovarian, and gastric cancers. These findings suggest that PTGIS could be taken as a potential biomarker of prognosis and tumor-infiltrating immune cells.
PTGIS expression was investigated in different datasets of the Oncomine database, and its expression levels in various tumors and corresponding normal tissues were analyzed by the Tumor Immune Estimation Resource (TIMER). Then, the clinical prognostic value of PTGIS was assessed with online public databases. In addition, we initially explored the correlation between PTGIS and tumor-infiltrating immune cells by TIMER and Gene Expression Profiling Interactive Analysis (GEPIA).
前列腺素 I2 合酶（PTGIS）是合成前列腺素 I2 的关键基因，在炎症和免疫调节中具有多种作用。然而，关于 PTGIS 在多种癌症中的预后价值及其与肿瘤浸润免疫细胞的相关性的研究仍然很少。
Oncomine 数据库的多个数据集显示，与正常组织相比，肺癌和卵巢癌中 PTGIS 的表达水平较低。Kaplan-Meier plotter 显示，PTGIS 高表达与肺癌、卵巢癌和胃癌患者的总生存期和无进展生存期不良相关。此外，PTGIS 表达与巨噬细胞浸润水平呈显著正相关，与多种免疫标志物，特别是肿瘤相关巨噬细胞（TAMs）和 T 调节细胞（Tregs）强烈相关。
PTGIS 的高表达可能促进肿瘤微环境中 TAMs 和 Tregs 的浸润，导致肺癌、卵巢癌和胃癌患者的预后恶化。这些发现表明，PTGIS 可作为预后和肿瘤浸润免疫细胞的潜在生物标志物。
通过 Oncomine 数据库的不同数据集研究 PTGIS 的表达，并通过肿瘤免疫估计资源（TIMER）分析其在各种肿瘤和相应正常组织中的表达水平。然后，通过在线公共数据库评估 PTGIS 的临床预后价值。此外，我们还通过 TIMER 和基因表达谱交互分析（GEPIA）初步探讨了 PTGIS 与肿瘤浸润免疫细胞的相关性。
