Algeri Paola, Ornaghi Sara, Bernasconi Davide Paolo, Cappellini Fabrizio, Signorini Stefano, Brambilla Paolo, Urban Gabriele, Vergani Patrizia
Department of Obstetrics and Gynecology, University of Milan-Bicocca , Monza , Italy .
Hypertens Pregnancy. 2014 Aug;33(3):360-70. doi: 10.3109/10641955.2014.903962. Epub 2014 Apr 11.
PTX3, sFlt-1 and PlGF levels in maternal blood are altered in some obstetric diseases, such as preeclampsia (PE). Nonetheless, only few data on their expression in the fetal compartment have been reported so far.
An observational study was performed by prospectively collecting maternal and fetal serum samples in 51 singleton pregnancies divided into two groups: 22 PE women and 29 healthy controls. The relationships between maternal and fetal marker serum levels were evaluated by Spearman correlation.
A feto-maternal correlation was neither identified for PTX3 in either PE or control groups (1.1 versus 3.8 ng/ml, p = 0.17 and 0.9 versus 1.3 ng/ml, p = 0.30, respectively), nor for sFlt-1 and PlGF in healthy pregnancies (158.2 versus 3326.0 pg/ml, p = 0.28 and 11.0 versus 230.9 pg/ml, p = 0.51). In contrast, PE patients showed a significant positive feto-maternal correlation for both sFlt-1 and PlGF (324.1 versus 10 825.0 pg/ml and 7.8 versus 31.6 pg/ml, respectively, p = 0.02 for both markers).
According to our results, an independent fetal production of the analyzed soluble angiogenic markers can be hypothesized in pregnancies complicated by PE.
在一些产科疾病如子痫前期（PE）中，母体血液中的PTX3、sFlt-1和PlGF水平会发生改变。然而，迄今为止，关于它们在胎儿体内表达的数据报道较少。
进行了一项观察性研究，前瞻性收集了51例单胎妊娠的母体和胎儿血清样本，分为两组：22例PE患者和29例健康对照。通过Spearman相关性评估母体和胎儿标志物血清水平之间的关系。
在PE组或对照组中，PTX3均未发现母胎相关性（分别为1.1对3.8 ng/ml，p = 0.17；0.9对1.3 ng/ml，p = 0.30），在健康妊娠中sFlt-1和PlGF也未发现母胎相关性（分别为158.2对3326.0 pg/ml，p = 0.28；11.0对230.9 pg/ml，p = 0.51）。相比之下，PE患者的sFlt-1和PlGF均显示出显著的母胎正相关性（分别为324.1对10825.0 pg/ml和7.8对31.6 pg/ml，两种标志物p均 = 0.02）。
根据我们的结果，可以推测在合并PE的妊娠中，所分析的可溶性血管生成标志物存在独立的胎儿产生情况。
