中国汉族人群中TREM2基因多态性rs75932628与晚发型阿尔茨海默病的关联研究
Association study of TREM2 polymorphism rs75932628 with late-onset Alzheimer's disease in Chinese Han population.
作者信息
Ma Jianfang, Zhou Yi, Xu Jun, Liu Xiaohong, Wang Ying, Deng Yulei, Wang Gang, Xu Wei, Ren Rujin, Liu Xiaoying, Zhang Yu, Wang Cheng, Tang Huidong, Chen Shengdi
出版信息
Neurol Res. 2014 Oct;36(10):894-6. doi: 10.1179/1743132814Y.0000000376. Epub 2014 Apr 13.
OBJECTIVE
We conducted a case-control study to investigate whether TREM2 polymorphism (rs75932628-T) was associated with late onset Alzheimer's disease in Chinese Southern Han population.
METHODS
PCR-restriction fragment length polymorphism assay was performed to genotype rs75932628 in 279 cases with late onset Alzheimer's diseases patients and 346 control subjects in Shanghai and Nanjing.
RESULTS
There was no rs75932628-T variant detected in our sample. However, APOEϵ4 was shown closely associated with the risk of Alzheimer's disease (Chi-square = 60·288, P = 0·000).
CONCLUSION
Our study suggested that TREM2 (rs75932628-T) was rare in Chinese Han population. Further association studies with large samples are needed to further study the association of TREM2 with late-onset Alzheimer's disease.
目的
我们开展了一项病例对照研究，以调查触发受体表达上调基因2（TREM2）多态性（rs75932628 - T）是否与中国南方汉族人群晚发性阿尔茨海默病相关。
方法
采用聚合酶链反应 - 限制性片段长度多态性分析方法，对上海和南京的279例晚发性阿尔茨海默病患者及346名对照者的rs75932628进行基因分型。
结果
在我们的样本中未检测到rs75932628 - T变异。然而，载脂蛋白Eε4（APOEϵ4）与阿尔茨海默病风险密切相关（卡方检验=60.288，P = 0.000）。
结论
我们的研究表明，TREM2（rs75932628 - T）在中国汉族人群中罕见。需要进一步开展大样本关联研究，以深入探究TREM2与晚发性阿尔茨海默病的关联。
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