Department of Vision Sciences, Glasgow-Caledonian University, Glasgow, UK.
Ocul Surf. 2014 Apr;12(2):100-11. doi: 10.1016/j.jtos.2013.11.002. Epub 2013 Dec 28.
To review outcomes of studies where fluorescein-tear breakup time (fTBUT) measurements had been made before and after treatment with artificial tears.
Peer-reviewed articles were identified that reported average values for fTBUT before and after approximately 1 month of treatment of dry eye with aqueous-based artificial tears. 48 data sets were used for calculating the net (percentage) change in fTBUT, with 21 including information of variability (as reported SD of average value) of the fTBUT data suitable for a meta-analysis.
Prior to treatment, average fTBUT values ranged from 0.9 s to 11.8 s (group mean 4.7 +/- 1.7 s, n = 48 data sets). After treatment, these values ranged from 2.2 to 10.7 s (group mean 6.1 +/- 2.3 s; P<.001), with net increase for the treatment effect being 1.4 +/- 1.2 s (range - 1.4 to + 4.5 s). Similar changes were reported regardless of the type of product type. The meta-analysis confirmed a net effect at 1.3 s, with the magnitude of the variability (as a weighted SE) having a similar overall value of 1.1 s.
Following use of 'artificial tears' by dry eye patients, a small but predictable increase in tear film stability has generally been reported, the net magnitude of which is close to a 33% improvement.
回顾使用人工泪液治疗干眼症前后进行荧光素泪膜破裂时间（fTBUT）测量的研究结果。
确定了已发表的同行评审文章，这些文章报告了使用基于水的人工泪液治疗干眼症约 1 个月后 fTBUT 的平均数值。使用了 48 个数据集来计算 fTBUT 的净（百分比）变化，其中 21 个数据集包括 fTBUT 数据的可变性（如平均数值的报道 SD）信息，适合进行荟萃分析。
治疗前，平均 fTBUT 值范围为 0.9 秒至 11.8 秒（组平均值 4.7 +/- 1.7 秒，n = 48 个数据集）。治疗后，这些值的范围为 2.2 秒至 10.7 秒（组平均值 6.1 +/- 2.3 秒；P<.001），治疗效果的净增加为 1.4 +/- 1.2 秒（范围 - 1.4 至 + 4.5 秒）。无论产品类型如何，都报告了类似的变化。荟萃分析证实了 1.3 秒的净效应，其可变性（作为加权 SE）的大小具有相似的总体值 1.1 秒。
干眼症患者使用“人工泪液”后，通常报告泪膜稳定性有较小但可预测的增加，其净幅度接近 33%的改善。
