Sage J I, McHale D M, Sonsalla P, Vitagliano D, Heikkila R E
Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick.
Neurology. 1989 Jul;39(7):888-91. doi: 10.1212/wnl.39.7.888.
We report the clinical spectrum of 3 patients with Parkinson's disease who experienced complex patterns of levodopa-related dystonia. Dystonia was unrelieved by multiple medication regimens but responded well to continuous, duodenal levodopa infusions. Patients were able to remain mobile without severe dystonia despite a very narrow window of benefit between the levodopa concentration necessary to achieve the "on" state and that which caused the onset of dystonic spasms.
我们报告了3例帕金森病患者的临床情况，这些患者经历了复杂的左旋多巴相关肌张力障碍模式。多种药物治疗方案均无法缓解肌张力障碍，但持续十二指肠左旋多巴输注对此反应良好。尽管在达到“开”状态所需的左旋多巴浓度与引发肌张力障碍性痉挛的浓度之间存在非常狭窄的获益窗口，但患者仍能在无严重肌张力障碍的情况下保持活动能力。
