Schiebler M L, Tomaszewski J E, Bezzi M, Pollack H M, Kressel H Y, Cohen E K, Altman H G, Gefter W B, Wein A J, Axel L
Department of Radiology, University of North Carolina Medical School, Chapel Hill.
Radiology. 1989 Jul;172(1):131-7. doi: 10.1148/radiology.172.1.2472644.
High-resolution magnetic resonance (MR) imaging of 24 fresh radical prostatectomy specimens was performed on an experimental 1.9-T system. Direct correlation between the findings in 7-micron-thick macrosections and their corresponding MR images was possible. Fourteen patients had macroscopic evidence of cancer. In all 14 cases, the carcinoma nodules appeared as areas of low signal intensity on images obtained with a repetition time of 2,500 msec and an echo time of 80 msec. Ten of 14 nodules had well-defined margins and consisted of densely packed glandular elements, which displaced the surrounding normal glandular material of higher signal intensity. Ten specimens displayed benign prostatic hyperplasia (BPH). The MR characteristics of this entity were quite variable but relatively predictable, depending on the distribution and size of the glandular elements, as well as the composition of the surrounding stroma. In BPH, the changes began in the central portion of the gland. The areas of highest signal intensity corresponded to dilated glandular elements (cystic ectasia), while the areas of lowest signal intensity corresponded to collagen (scar) and fibromuscular stroma. Nodules of mixed glandular BPH and fibromuscular BPH were found to have signal intensities similar to those of well-differentiated nodules of prostatic adenocarcinoma.
在一台实验性1.9-T系统上对24个新鲜前列腺癌根治术标本进行了高分辨率磁共振（MR）成像。7微米厚的大体切片的检查结果与其相应的MR图像之间存在直接关联。14例患者有肉眼可见的癌症证据。在所有14例病例中，癌结节在重复时间为2500毫秒、回波时间为80毫秒的图像上表现为低信号强度区域。14个结节中有10个边界清晰，由紧密排列的腺性成分组成，这些成分推移了周围信号强度较高的正常腺性物质。10个标本显示为良性前列腺增生（BPH）。该实体的MR特征变化很大，但相对可预测，这取决于腺性成分的分布和大小以及周围基质的组成。在BPH中，变化始于腺体的中央部分。信号强度最高的区域对应于扩张的腺性成分（囊性扩张），而信号强度最低的区域对应于胶原（瘢痕）和纤维肌性基质。发现混合性腺性BPH和纤维肌性BPH的结节的信号强度与前列腺腺癌高分化结节的信号强度相似。
