Spalević L, Katić V
Acta Med Iugosl. 1989;43(2):121-6.
Various cytologic appearances of malignant melanomas represent a great diagnostic problem in the pathologist's everyday work. The new Pearse concept that the melanoblast/cyte is the APUD cell led the authors to the idea of using Grimelius' silver method, characteristic of APUD cells, in the diagnostic pathologic work of both melanotic and amelanotic malignant melanomas. The results are based on the examination of 20 tumours. All types of malignant melanomas were Grimelius reactive. The blanching by hydrogen peroxidase of Grimelius reactive cells makes this silver reaction specific in the study of melanomas.
恶性黑色素瘤的各种细胞学表现给病理学家的日常工作带来了巨大的诊断难题。Pearse提出的黑素母细胞/黑素细胞是APUD细胞这一新概念，促使作者想到在黑素性和无黑素性恶性黑色素瘤的诊断病理工作中使用Grimelius银染色法，这是APUD细胞的特征性染色方法。结果基于对20个肿瘤的检查。所有类型的恶性黑色素瘤对Grimelius染色均呈阳性反应。Grimelius阳性反应细胞用过氧化氢处理后的褪色现象使得这种银染色反应在黑色素瘤研究中具有特异性。
