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一项关于宗教信仰维度与常见精神疾病及物质使用障碍的多变量双生子研究。

A multivariate twin study of the dimensions of religiosity and common psychiatric and substance use disorders.

作者信息

Vance Todd, Maes Hermine H, Kendler Kenneth S

机构信息

*Salem VA Medical Center, Virginia; †Departments of Psychiatry and Human Genetics, Virginia Commonwealth University, Richmond, VA; and ‡Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA.

出版信息

J Nerv Ment Dis. 2014 May;202(5):360-7. doi: 10.1097/NMD.0000000000000131.

Abstract

The authors sought to decompose the covariance between seven dimensions of religiosity and two internalizing psychiatric disorders (major depression and phobia) and two externalizing substance use disorders (alcohol dependence and nicotine dependence). Significant negative correlations, accounted for by shared additive genetic effects, were found between alcohol dependence and six of the seven religiosity factors. Additive genetic effects accounted for significant negative correlations between nicotine dependence and one religiosity factor, social religiosity, and between phobia and unvengefulness. Common environmental effects accounted for a significant positive correlation between phobia and the factor God as judge. No statistically significant covariance due to genetic or environmental effects was found for major depression and any of the seven religiosity factors. Overall, although several statistically significant bivariate relationships were found, the estimates of covariance due to additive genetic effects were modest.

摘要

作者试图分解宗教信仰七个维度与两种内化性精神障碍(重度抑郁症和恐惧症)以及两种外化性物质使用障碍(酒精依赖和尼古丁依赖)之间的协方差。发现酒精依赖与七个宗教信仰因素中的六个之间存在显著的负相关,这是由共享的加性遗传效应造成的。加性遗传效应导致尼古丁依赖与一个宗教信仰因素(社会宗教信仰)之间以及恐惧症与不报复之间存在显著的负相关。共同环境效应导致恐惧症与“上帝作为审判者”这一因素之间存在显著的正相关。未发现重度抑郁症与七个宗教信仰因素中的任何一个因遗传或环境效应而产生的具有统计学意义的协方差。总体而言,尽管发现了几种具有统计学意义的双变量关系,但由加性遗传效应导致的协方差估计值较小。

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