来自1型人类免疫缺陷病毒（HIV-1）、HIV-2和猴免疫缺陷病毒（SIVMAC）的逆转录酶对膦甲酸钠和3'-叠氮-3'-脱氧胸苷三磷酸敏感，易受其抑制。
Reverse transcriptases from human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIVMAC) are susceptible to inhibition by foscarnet and 3'-azido-3'-deoxythymidine triphosphate.
作者信息
Vrang L, Oberg B, Löwer J, Kurth R
机构信息
Department of Virology, Karolinska Institute, Stockholm, Sweden.
出版信息
Antimicrob Agents Chemother. 1988 Nov;32(11):1733-4. doi: 10.1128/AAC.32.11.1733.
Abstract
Reverse transcriptases from human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV) were investigated with respect to susceptibilities to the reverse transcriptase inhibitors foscarnet and 3'-azido-3'-deoxythymidine triphosphate (AZTTP). The different reverse transcriptases had the same sensitivity to foscarnet (50% inhibition at 0.10 to 0.16 microM). The Ki values for AZTTP were 0.01 to 0.02 microM for HIV-1 reverse transcriptase and 0.02 to 0.03 microM for HIV-2 and SIVMAC reverse transcriptases.
摘要
针对1型人类免疫缺陷病毒（HIV-1）、HIV-2和猴免疫缺陷病毒（SIV）的逆转录酶，研究了它们对逆转录酶抑制剂膦甲酸和3'-叠氮-3'-脱氧胸苷三磷酸（AZTTP）的敏感性。不同的逆转录酶对膦甲酸的敏感性相同（在0.10至0.16微摩尔时抑制50%）。AZTTP对HIV-1逆转录酶的Ki值为0.01至0.02微摩尔，对HIV-2和SIVMAC逆转录酶的Ki值为0.02至0.03微摩尔。
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