双脱氧核苷在体外对2型人类免疫缺陷病毒（HIV - 2）的抑制作用比对HIV - 1的抑制作用小。
Dideoxynucleosides are less inhibitory in vitro against human immunodeficiency virus type 2 (HIV-2) than against HIV-1.
作者信息
Richman D D
机构信息
Department of Pathology, University of California San Diego 92093.
出版信息
Antimicrob Agents Chemother. 1987 Dec;31(12):1879-81. doi: 10.1128/AAC.31.12.1879.
Abstract
The antiviral activities of various dideoxynucleosides against LAV strains of human immunodeficiency viruses type 1 (HIV-1) and type 2 (HIV-2) were evaluated. Significantly more 3'-azido-3'-deoxythymidine was required to inhibit the replication of HIV-2 than HIV-1 in three human cell lines. HIV-2 also appeared more resistant than HIV-1 to other dideoxynucleosides. These results suggest that dideoxynucleosides may be less effective in vivo for HIV-2 infection and that a broader range of clinical isolates of human retroviruses should be examined for drug susceptibility in vitro.
摘要
评估了各种双脱氧核苷对1型人类免疫缺陷病毒（HIV-1）和2型人类免疫缺陷病毒（HIV-2）的拉夫（LAV）毒株的抗病毒活性。在三种人类细胞系中，抑制HIV-2复制所需的3'-叠氮基-3'-脱氧胸苷比抑制HIV-1复制所需的要多得多。HIV-2对其他双脱氧核苷的耐药性似乎也比HIV-1更强。这些结果表明，双脱氧核苷在体内对HIV-2感染的效果可能较差，并且应该对更广泛的人类逆转录病毒临床分离株进行体外药敏试验。
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