Smirnov A V
Arkh Patol. 1989;51(3):16-22.
The paper presents immunofluorescence findings on the distribution of medium-sized vimentinic and cytokeratinic filaments in the cells of epithelioid sarcoma. Two morphologically different types of tumor cells have been shown to be distinguished by the pattern of their filament expression: fusiform fibroblastoid cells contain vimentin (a mesenchymal type of differentiation), but there is a coexpression of cytokeratin and vimentin (an epithelial type) in the so-called epithelioid cells. Double mesenchymal-and-epithelial differentiation of the cells makes it possible to suppose that this tumor is of mesodermal rather than mesenchymal origin as is generally accepted. The features found in the distribution of medium-sized filaments in the epithelioid sarcoma may be useful in the practical differential diagnosis of this tumor as compared to numerous morphologically similar neoplasms.
本文介绍了上皮样肉瘤细胞中中等大小波形蛋白和细胞角蛋白丝分布的免疫荧光研究结果。已证实两种形态不同的肿瘤细胞可通过其丝蛋白表达模式加以区分：梭形成纤维样细胞含有波形蛋白（一种间充质分化类型），但在所谓的上皮样细胞中细胞角蛋白和波形蛋白呈共表达（上皮类型）。细胞的双间充质和上皮分化使得有可能推测该肿瘤起源于中胚层而非如普遍认为的间充质。与众多形态相似的肿瘤相比，上皮样肉瘤中中等大小丝蛋白分布的这些特征可能有助于该肿瘤的实际鉴别诊断。
