Yu Hea Min, Park Kang Seo, Lee Jae Min
Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine, Eulji University Hospital, Republic of Korea.
Arq Bras Endocrinol Metabol. 2014 Feb;58(1):30-6. doi: 10.1590/0004-2730000002836.
Therefore, we evaluated the relationship between the subclinical hypothyroidism and red cell distribution width (RDW) levels in a healthy population.
The medical records of 23,343 consecutive health subjects were reviewed. Subjects were classified into four thyroid stimulating hormone (TSH) groups to determine the correlation between TSH and other variables in detail (0.3 to < 2.5 mU/L, 2.5 to < 5 mU/L, 5 to < 7.5 mU/L, and ≥ 7.5 mU/L).
In the multivariate linear regression analysis, RDW was associated with TSH levels, and e-GFR was inversely associated with TSH levels, respectively (standardized beta coefficient = 0.102, -0.019; p < 0.001, p < 0.001). After adjusting for age and sex, in the four groups, TSH levels were significantly correlated with RDW, estimated glomerular filtration rate (e-GFR), and free thyroxine (fT4) levels in all groups. Furthermore in the 4 th group, RDW levels were more strongly associated with TSH levels than in the other groups (p = 0.006).
RDW levels are correlated with euthyroid and subclinical thyroid status. Notably, RDW is more correlated with subclinical hypothyroidism than the euthyroid status. This study presents the relationship between the RDW levels and thyroid function using TSH level in a large healthy population.
因此，我们评估了健康人群中亚临床甲状腺功能减退与红细胞分布宽度（RDW）水平之间的关系。
回顾了23343例连续健康受试者的病历。将受试者分为四个促甲状腺激素（TSH）组，以详细确定TSH与其他变量之间的相关性（0.3至<2.5 mU/L、2.5至<5 mU/L、5至<7.5 mU/L和≥7.5 mU/L）。
在多变量线性回归分析中，RDW与TSH水平相关，而估算肾小球滤过率（e-GFR）与TSH水平呈负相关（标准化β系数分别为0.102、-0.019；p<0.001，p<0.001）。在调整年龄和性别后，在这四组中，TSH水平与所有组的RDW、估算肾小球滤过率（e-GFR）和游离甲状腺素（fT4）水平均显著相关。此外，在第4组中，RDW水平与TSH水平的相关性比其他组更强（p=0.006）。
RDW水平与甲状腺功能正常及亚临床甲状腺状态相关。值得注意的是，与甲状腺功能正常状态相比，RDW与亚临床甲状腺功能减退的相关性更强。本研究利用TSH水平展示了大量健康人群中RDW水平与甲状腺功能之间的关系。
