Martinez Carlos, Mooney Carmel T, Shiel Robert E, Tang Pak Kan, Mooney Louise, O'Neill Emma J
School of Veterinary Medicine, University College Dublin Veterinary Hospital, Belfield, Co. Dublin, Ireland.
Can Vet J. 2019 Sep;60(9):964-971.
In humans, increased red blood cell distribution width (RDW) values are associated with higher morbidity and mortality in a variety of pathological processes. The main objective of this study was to evaluate RDW in dogs with a diverse range of pathologies. Clinical data from 276 dogs were retrospectively evaluated. Significantly higher RDW values were found in dogs with primary immune-mediated hemolytic anemia ( < 0.0001), immune-mediated thrombocytopenia ( < 0.0004), hyperadrenocorticism ( < 0.0001), hypothyroidism ( = 0.0220), hepatic vascular anomaly ( < 0.0001), pneumonia ( < 0.0001), chronic kidney disease ( = 0.0005), multi-centric lymphoma ( = 0.0002), and myxomatous mitral valve degeneration ( = 0.0032). However, there was extensive overlap with the values from healthy dogs, limiting the diagnostic value of RDW in this setting. Although RDW may have a role as a potential prognostic indicator, further studies would be necessary to address this.
在人类中，红细胞分布宽度（RDW）值升高与多种病理过程中较高的发病率和死亡率相关。本研究的主要目的是评估患有多种病理疾病的犬的RDW。对276只犬的临床数据进行了回顾性评估。发现原发性免疫介导性溶血性贫血（<0.0001）、免疫介导性血小板减少症（<0.0004）、肾上腺皮质功能亢进（<0.0001）、甲状腺功能减退（=0.0220）、肝血管异常（<0.0001）、肺炎（<0.0001）、慢性肾病（=0.0005）、多中心淋巴瘤（=0.0002）和黏液瘤性二尖瓣退变（=0.0032）的犬的RDW值显著更高。然而，这些值与健康犬的值有广泛重叠，限制了RDW在此情况下的诊断价值。虽然RDW可能作为一种潜在的预后指标发挥作用，但需要进一步研究来解决这一问题。
