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心脏干细胞及其临床应用。

Cardiac stem cells and their clinical use.

作者信息

Pasternak Jacyr

机构信息

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

出版信息

Einstein (Sao Paulo). 2014 Jan-Mar;12(1):134-5. doi: 10.1590/s1679-45082014md2739.

DOI:10.1590/s1679-45082014md2739
PMID:24728261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4898254/
Abstract

Stem cells have been used to correct the ravages of atherosclerotic heart disease and other diseases that involve acute deficit of myocardial muscle, such as myocarditis. Previous attempts at using bone marrow derived from stem cells have not been particularly successful. New technologies using cardiac stem cells seem to offer a better perspective of obtaining such regeneration.

摘要

干细胞已被用于纠正动脉粥样硬化性心脏病以及其他涉及心肌急性缺损的疾病（如心肌炎）所造成的破坏。以往尝试使用源自干细胞的骨髓，但效果并不特别理想。使用心脏干细胞的新技术似乎为实现这种再生提供了更好的前景。

相似文献

1
Cardiac stem cells and their clinical use.心脏干细胞及其临床应用。
Einstein (Sao Paulo). 2014 Jan-Mar;12(1):134-5. doi: 10.1590/s1679-45082014md2739.
2
Myocardial repair and regeneration: bone marrow or cardiac stem cells?心肌修复与再生：骨髓干细胞还是心脏干细胞？
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Stem Cell Res Ther. 2010 Sep 23;1(4):29. doi: 10.1186/scrt29.
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Bone marrow-derived stem cell therapy in ischemic heart disease.缺血性心脏病中的骨髓源性干细胞治疗。
Regen Med. 2006 May;1(3):337-45. doi: 10.2217/17460751.1.3.337.
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Autologous bone marrow-derived stem cells for ischemic heart failure: REGENERATE-IHD trial.用于缺血性心力衰竭的自体骨髓来源干细胞：REGENERATE-IHD试验。
Regen Med. 2009 Jan;4(1):119-27. doi: 10.2217/17460751.4.1.119.
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Curr Pharm Des. 2011 Oct;17(30):3252-7. doi: 10.2174/138161211797904181.
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Stem cells for heart cell therapies.用于心脏细胞治疗的干细胞。
Tissue Eng Part B Rev. 2008 Dec;14(4):393-406. doi: 10.1089/ten.teb.2008.0262.
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Stem cells for myocardial regeneration.用于心肌再生的干细胞。
Circ Res. 2002 Dec 13;91(12):1092-102. doi: 10.1161/01.res.0000046045.00846.b0.
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Therapeutic potential of stem cells in elderly patients with cardiovascular disease.干细胞在老年心血管疾病患者中的治疗潜力。
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Cardiac accumulation of bone marrow mononuclear progenitor cells after intracoronary or intravenous injection in pigs subjected to acute myocardial infarction with subsequent reperfusion.在经历急性心肌梗死并随后再灌注的猪中，冠状动脉内或静脉内注射后骨髓单个核祖细胞在心脏中的积聚。
Cardiovasc Revasc Med. 2007 Jan-Mar;8(1):21-7. doi: 10.1016/j.carrev.2006.09.001.

引用本文的文献

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Inhibiting the mobilization of Ly6C(high) monocytes after acute myocardial infarction enhances the efficiency of mesenchymal stromal cell transplantation and curbs myocardial remodeling.抑制急性心肌梗死后Ly6C(高)单核细胞的动员可提高间充质基质细胞移植的效率并抑制心肌重塑。
Am J Transl Res. 2015 Mar 15;7(3):587-97. eCollection 2015.

本文引用的文献

1
Comparison of human adipose-derived stem cells and bone marrow-derived stem cells in a myocardial infarction model.人脂肪来源干细胞与骨髓来源干细胞在心肌梗死模型中的比较。
Cell Transplant. 2014 Feb;23(2):195-206. doi: 10.3727/096368912X659871. Epub 2012 Dec 4.
2
Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial.经心内膜注射异体与自体骨髓间充质干细胞治疗缺血性心肌病的比较：POSEIDON 随机试验。
JAMA. 2012 Dec 12;308(22):2369-79. doi: 10.1001/jama.2012.25321.
3
Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial.缺血性心肌病患者的心脏干细胞（SCIPIO）：一项随机 1 期试验的初步结果。
Lancet. 2011 Nov 26;378(9806):1847-57. doi: 10.1016/S0140-6736(11)61590-0. Epub 2011 Nov 14.
4
Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial.急性心肌梗死后 2 至 3 周经冠状动脉内自体骨髓单个核细胞移植对左心室功能的影响：晚期时间随机试验。
JAMA. 2011 Nov 16;306(19):2110-9. doi: 10.1001/jama.2011.1670. Epub 2011 Nov 14.
5
10 years of intracoronary and intramyocardial bone marrow stem cell therapy of the heart: from the methodological origin to clinical practice.10 年的心脏冠状动脉内和心肌内骨髓干细胞治疗：从方法学起源到临床实践。
J Am Coll Cardiol. 2011 Sep 6;58(11):1095-104. doi: 10.1016/j.jacc.2011.06.016.
6
Clinical impact of combined transplantation of autologous skeletal myoblasts and bone marrow mononuclear cells in patients with severely deteriorated ischemic cardiomyopathy.自体骨骼肌母细胞与骨髓单个核细胞联合移植治疗重度恶化缺血性心肌病的临床影响。
Surg Today. 2011 Aug;41(8):1029-36. doi: 10.1007/s00595-010-4526-3. Epub 2011 Jul 20.
7
Long-term results of autologous stem cell transplantation in the treatment of patients with congestive heart failure.自体干细胞移植治疗充血性心力衰竭患者的长期结果。
Transplant Proc. 2011 Apr;43(3):931-4. doi: 10.1016/j.transproceed.2011.01.115.
8
Stem cell therapy in acute myocardial infarction: a review of clinical trials.干细胞治疗急性心肌梗死：临床试验综述。
Transl Res. 2010 Jan;155(1):10-9. doi: 10.1016/j.trsl.2009.06.009.
9
Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial.急性心肌梗死患者冠状动脉内注射骨髓源性祖细胞后临床结局改善：REPAIR-AMI试验1年最终结果
Eur Heart J. 2006 Dec;27(23):2775-83. doi: 10.1093/eurheartj/ehl388. Epub 2006 Nov 10.
10
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.急性心肌梗死时冠状动脉内注射单个核骨髓细胞
N Engl J Med. 2006 Sep 21;355(12):1199-209. doi: 10.1056/NEJMoa055706.