Ansar Akram, Farshchian Mahmood, Ghasemzadeh Mostafa, Sobhan Mohammad Reza
Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
J Res Health Sci. 2014 Spring;14(2):111-4.
There are many risk factors besides age and immune suppression for herpes zoster. Family history as a risk factor is suggested in some recent studies. The aim of this study was to evaluate the association between herpes zoster and family history.
This case-control study was undertaken in Farshchian Hospital, Hamadan, Iran. "Case group" included patients with confirmed diagnosis of herpes zoster. "Control group" was chosen among other dermatologic patients or their companions without any history of herpes zoster. Immune deficiency was the main excluding criteria. Information about age, gender, dermatome involved (only in patient group), history of chronic dermatologic or systemic diseases and family history of herpes zoster was asked using special questionnaires.
Case and control groups included 217 and 200 participants respectively. Mean age of cases and controls was 49.08±15.59 and 49.96±15.54 years old respectively (P=0.936). 53.5% of cases and 54.5% of controls were women (P=0.845). Most frequent dermatomes involved in patients were thoracic (85/217; 39.25%) and cervical dermatomes (55/217; 25.3%). Frequency of herpes zoster in first-degree blood relatives in cases and controls was 65/217 (30%) and 16/200 (8%) respectively (OR=4.91; 95% CI: 2.73, 8.85; P=0.001).
Our findings indicated a significantly higher proportion of patients with family history of herpes zoster comparing to controls. This study confirms family history as a risk factor for herpes zoster. Therefore, the old patients with positive family history of herpes zoster may be appropriate candidates for vaccination with Zostavax. However, more evidence based on large cohort studies in needed to confirm our findings.
除年龄和免疫抑制外，带状疱疹还有许多风险因素。近期一些研究提示家族史是一个风险因素。本研究旨在评估带状疱疹与家族史之间的关联。
本病例对照研究在伊朗哈马丹的法尔什恰安医院进行。“病例组”包括确诊为带状疱疹的患者。“对照组”从其他皮肤科患者或其同伴中选取，这些人无带状疱疹病史。免疫缺陷是主要排除标准。通过特殊问卷询问年龄、性别、受累皮节（仅病例组）、慢性皮肤病或全身性疾病史以及带状疱疹家族史等信息。
病例组和对照组分别有217名和200名参与者。病例组和对照组的平均年龄分别为49.08±15.59岁和49.96±15.54岁（P = 0.936）。病例组53.5%为女性，对照组54.5%为女性（P = 0.845）。患者中最常受累的皮节是胸部（85/217；39.25%）和颈部皮节（55/217；25.3%）。病例组和对照组一级血亲中带状疱疹的发生率分别为65/217（30%）和16/200（8%）（OR = 4.91；95%CI：2.73，8.85；P = 0.001）。
我们的研究结果表明，与对照组相比，有带状疱疹家族史的患者比例显著更高。本研究证实家族史是带状疱疹的一个风险因素。因此，有带状疱疹家族史的老年患者可能是接种重组带状疱疹疫苗的合适人选。然而，需要更多基于大型队列研究的证据来证实我们的研究结果。
