中国北京一项关于家族史作为带状疱疹风险因素及相关结局的病例对照研究。
A case control study on family history as a risk factor for herpes zoster and associated outcomes, Beijing, China.
作者信息
Suo Luodan, Lu Li, Li Juan, Sun Mu, Wang Haihong, Peng Xinhui, Yang Fan, Pang Xinghuo, Marin Mona, Wang Chengbin
机构信息
Beijing Center for Disease Control and Prevention, Beijing, China.
Xicheng District Center for Disease Control and Prevention, Beijing, China.
出版信息
BMC Infect Dis. 2017 May 9;17(1):334. doi: 10.1186/s12879-017-2416-7.
BACKGROUND
Hospital-based case control studies have found family history of herpes zoster (HZ) was associated with risk of HZ, but the role of family history is not fully examined for other HZ-associated outcomes such as recurrent HZ, occurrence of postherpetic neuralgia (PHN), and HZ with different pain severities.
METHODS
We conducted a population-based matched case control study. HZ cases that occurred during December 1, 2011 to November 30, 2012 were identified by face-to-face interview with all residents of eight selected communities/villages from three districts of Beijing, China. Medical records were reviewed for those who sought healthcare for HZ. For each case-patient, three, age-matched controls (±5 years) without HZ were enrolled from the same community/village of the matched case. Data on family history of HZ were collected by interview and only defined among first-degree relatives.
RESULTS
A total of 227 case-patients and 678 matched controls were enrolled. Case-patients were more likely to report a family history of HZ [odds ratio (OR) =2.4, P = 0.002]. Compared with controls, association of family history decreased from HZ with PHN to HZ without PHN (OR = 6.0 and 2.3, respectively; P = 0.002 for trend), from recurrent HZ to primary HZ (OR = 9.4 and 2.2, respectively; P = 0.005 for trend), and from HZ with moderate or severe pain to HZ with mild or no pain (OR = 3.2 and 0.8, respectively; P < 0.001 for trend).
CONCLUSIONS
Family history of HZ was associated with HZ occurrence and was more likely in HZ case-patients with PHN, recurrences, and painful HZ.
背景
基于医院的病例对照研究发现，带状疱疹（HZ）家族史与HZ发病风险相关，但对于其他与HZ相关的结局，如复发性HZ、带状疱疹后神经痛（PHN）的发生以及不同疼痛严重程度的HZ，家族史的作用尚未得到充分研究。
方法
我们开展了一项基于人群的匹配病例对照研究。通过对中国北京三个区八个选定社区/村庄的所有居民进行面对面访谈，确定了2011年12月1日至2012年11月30日期间发生的HZ病例。对因HZ寻求医疗服务的患者进行病历审查。对于每例病例患者，从匹配病例所在的同一社区/村庄招募三名年龄匹配（±5岁）且无HZ的对照。通过访谈收集HZ家族史数据，且仅在一级亲属中定义。
结果
共纳入227例病例患者和678例匹配对照。病例患者更有可能报告有HZ家族史[比值比（OR）=2.4，P = 0.002]。与对照相比，家族史与HZ伴PHN的关联从HZ伴PHN到无PHN的HZ有所降低（OR分别为6.0和2.3；趋势P = 0.002），从复发性HZ到初发性HZ（OR分别为9.4和2.2；趋势P = 0.005），以及从伴有中度或重度疼痛的HZ到伴有轻度或无疼痛的HZ（OR分别为3.2和0.8；趋势P < 0.001）。
结论
HZ家族史与HZ发病相关，在伴有PHN、复发及疼痛性HZ的HZ病例患者中更常见。
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