Beijing National Laboratory for Molecular Sciences and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.
Adv Mater. 2014 Jun 25;26(24):4163-7. doi: 10.1002/adma.201400323. Epub 2014 Apr 14.
The extracellular matrix is mimicked by a novel dendrimer-based hydrogel, which exhibits a highly interconnected porous network, enhanced mechanical stiffness, and a low swelling ratio. The hydrogel system supports the proliferation and differentiation of mesenchymal stem cells without any cytotoxic effects. This dendrimer-based hydrogel may serve as a model for developing new advanced materials with applications in tissue engineering.
新型基于树状大分子的水凝胶模拟细胞外基质，具有高度互联的多孔网络、增强的机械硬度和低溶胀比。水凝胶体系支持间充质干细胞的增殖和分化，没有任何细胞毒性作用。这种基于树状大分子的水凝胶可以作为开发具有组织工程应用的新型先进材料的模型。
