Division of Medical Devices for Diagnoses, Human Health Sciences, Graduate School of Medicine, Kyoto University, 53 Shogoin, Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Adv Exp Med Biol. 2014;812:247-252. doi: 10.1007/978-1-4939-0620-8_33.
Three experiments were conducted for the present study. First, to elucidate the mechanism and functional significance underlying ischemic vasoconstriction, we investigated the relationship between arteriolar constriction and tissue energy metabolism during bilateral common carotid artery occlusion in gerbils. Second, to identify differences in the postischemic recovery of physiologic parameters between short and prolonged brain ischemia, we measured changes in regional cerebral blood flow, microvessel diameter, brain temperature, and electrophysiologic response. Third, to explore the physiological mechanism of ischemic tolerance, we studied vascular response and intracerebral oxygenation states after acute global ischemia with and without pretreatment by mild ischemic stress. Here, we identify one of the physiologic mechanisms of the ischemic tolerance caused by brief ischemic pretreatment.
本研究进行了三项实验。首先，为了阐明缺血性血管收缩的机制和功能意义，我们研究了在沙土鼠双侧颈总动脉闭塞期间小动脉收缩与组织能量代谢之间的关系。其次，为了确定短时间和长时间脑缺血后生理参数的缺血后恢复之间的差异，我们测量了局部脑血流、微血管直径、脑温以及电生理反应的变化。第三，为了探讨缺血耐受的生理机制，我们研究了急性全脑缺血后伴有和不伴有轻度缺血预处理时的血管反应和颅内氧合状态。在这里，我们确定了短暂缺血预处理引起的缺血耐受的一种生理机制。
