续随子醇 A 和 B：一对 Z/E 立体异构的 indolizidine 生物碱，来自灌木续随子的根。
Suffrutines A and B: a pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa.
机构信息
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, 510632 Guangzhou (China); JNU-HKUST Joint Laboratory for Neuroscience & Innovation Drug Research, Jinan University, 510632 Guangzhou (China).
出版信息
Angew Chem Int Ed Engl. 2014 Jun 2;53(23):5796-9. doi: 10.1002/anie.201400048. Epub 2014 Apr 11.
Suffrutines A (1) and B (2), a pair of novel photochemical Z/E isomeric indolizidine alkaloids, with a unique and highly conjugated C20 skeleton, were isolated from the roots of Flueggea suffruticosa. The structures were elucidated by extensive analysis of NMR spectra and single-crystal X-ray diffraction. The light-induced isomerization and hypothetical biogenetic pathway to 1 and 2, as well as their activity for regulating the morphology of Neuro-2a cells are also discussed.
金锦香族 A（1）和 B（2），一对新型光致 Z/E 立体异构吲哚里西啶生物碱，具有独特的高度共轭 C20 骨架，从胡颓子科植物金锦香的根部分离得到。通过对 NMR 光谱和单晶 X 射线衍射的广泛分析，阐明了它们的结构。还讨论了它们的光致异构化和假设的生物合成途径，以及它们对调节 Neuro-2a 细胞形态的活性。
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