Wang Ying, Johnson John A, Spinale Francis G, Sutton Michael A, Lessner Susan M
Biomedical Engineering Program, University of South Carolina, Columbia, SC.
Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC.
Exp Mech. 2014 Apr 1;54(4):677-683. doi: 10.1007/s11340-013-9836-0.
The left anterior descending (LAD) coronary artery is the most frequently involved vessel in coronary artery dissection, a cause of acute coronary syndrome or sudden cardiac death. The biomechanical mechanisms underlying arterial dissection are not well understood. This study investigated the dissection properties of LAD specimens harvested from explanted hearts at the time of cardiac transplantation, from patients with primary dilated cardiomyopathy (n=12). Using a previously validated approach uniquely modified for these human LAD specimens, we quantified the local energy release rate, , within different arterial layers during experimental dissection events (tissue tearing). Results show that the mean values of during arterial dissection within the intima and within the media in human LADs are 20.7±16.5 J/m and 10.3±5.0 J/m, respectively. The difference in dissection resistance between tearing events occurring within the intima and within the media is statistically significant. Our data fall in the same order of magnitude as most previous measurements of adhesive strength in other human arteries, with the differences in measured values of within the layers most likely due to histologically observed differences in the structure and composition of arterial layers.
左前降支（LAD）冠状动脉是冠状动脉夹层中最常受累的血管，冠状动脉夹层是急性冠状动脉综合征或心源性猝死的一个原因。动脉夹层的生物力学机制尚未完全明确。本研究调查了从心脏移植时切除的心脏中获取的LAD标本（来自12例原发性扩张型心肌病患者）的夹层特性。我们采用一种先前已验证且专门针对这些人类LAD标本进行了修改的方法，在实验性夹层事件（组织撕裂）期间，对不同动脉层内的局部能量释放率G进行了量化。结果显示，人类LAD内膜和中膜内动脉夹层期间G的平均值分别为20.7±16.5 J/m和10.3±5.0 J/m。内膜内和中膜内发生的撕裂事件之间的夹层阻力差异具有统计学意义。我们的数据与之前大多数关于其他人类动脉黏附强度的测量结果处于同一数量级，各层内G测量值的差异很可能是由于组织学观察到的动脉层结构和组成差异所致。
