Bánovcin P, Visnovský P, Hanácek J, Plank L, Korpás J
Dept of Pediatrics, Faculty of Medicine, Comenius University, Martin, Czechoslovakia.
Eur Respir J. 1989 Jun;2(6):517-21.
Our recent in vitro studies on airway smooth muscles of cats with turpentine oil inflammation showed an increase of isometric tension of the lung strips to histamine application. This communication describes the effect of atropine, acetylsalicylic acid, FPL 55712, and phentolamine on the histamine contractions of the lung strips derived from control and experimental groups of cats. Pretreatment of the lung strips with atropine and acetylsalicylic acid had no significant effect on histamine induced contraction. FPL 55712 significantly decreased the mean values of isometric contractions after the low doses of histamine in experimental groups of strips. The isometric contractions after higher doses of histamine were not affected by FPL 55712 in both groups of strips. The significant increase of histamine contractions of the lung strips induced by experimental inflammation was reduced by phentolamine. The role of alpha adrenergic receptors in the increased responsiveness of the inflamed lung tissues to histamine is discussed.
我们最近对松节油炎症猫气道平滑肌进行的体外研究表明，向肺组织条施加组胺后，等长张力增加。本通讯描述了阿托品、乙酰水杨酸、FPL 55712和酚妥拉明对来自对照组和实验组猫的肺组织条组胺收缩的影响。用阿托品和乙酰水杨酸预处理肺组织条对组胺诱导的收缩无显著影响。FPL 55712显著降低了实验组低剂量组胺后等长收缩的平均值。两组肺组织条中高剂量组胺后的等长收缩不受FPL 55712影响。酚妥拉明可减轻实验性炎症诱导的肺组织条组胺收缩的显著增加。本文讨论了α肾上腺素能受体在炎症肺组织对组胺反应性增加中的作用。
