Bánovcin P, Visnovský P
Department of Pediatrics, Comenius University, Medical Faculty, Martin, Czechoslovakia.
Agents Actions. 1988 Apr;23(3-4):314-6. doi: 10.1007/BF02142574.
Previous in vitro studies on airway smooth muscles of cats with turpentine oil-induced inflammation of the airways have shown an increased sensitivity of the lung strips to histamine application. This effect was abolished by pretreatment with phentolamine. This communication describes the effect of prazosin and yohimbine on histamine responsiveness of strips of control and inflamed lungs. Prazosin had no effect on histamine-induced contraction of the control lung strips. However, the histamine-induced contraction of the experimental strips was depressed. Yohimbine depressed histamine-induced tension even in control lung strips. The role of alpha 1-adrenergic receptors in the increased responsiveness of the inflamed lung tissues to histamine is discussed.
先前对松节油诱导气道炎症的猫的气道平滑肌进行的体外研究表明，肺组织条对组胺的敏感性增加。酚妥拉明预处理可消除这种效应。本通讯描述了哌唑嗪和育亨宾对对照肺和炎症肺组织条组胺反应性的影响。哌唑嗪对组胺诱导的对照肺组织条收缩无影响。然而，组胺诱导的实验性组织条收缩受到抑制。育亨宾即使在对照肺组织条中也能抑制组胺诱导的张力。本文讨论了α1-肾上腺素能受体在炎症肺组织对组胺反应性增加中的作用。
