Haustein U F, Hlawa B
Dermatol Monatsschr. 1989;175(5):296-301.
This open clinical study was designed to evaluate and compare the efficacy and side-effects of lindane (1% and 0.3%), benzyl benzoate (20% and 10%) and permethrin (5% and 2.5%) after twice-, three times- and once application at bedtime, respectively, in the treatment of scabies in 104 adults and 70 children aged between 0 and 5 years. Treatment failures were registered afer lindane in 3 adults and 2 children, while benzyl benzoate and permethrin cured all patients as assessed after 3 weeks follow-up. The number of irritations and postscabious eccematous reactions was increased after benzyl benzoate. Permethrin revealed to be very reliable and exhibited only a few side-effects when applied once at bedtime. Because of the risk of the percutaneous absorption and neurotoxicity of lindane, the application of permethrin can be recommended as an useful alternative in premature infants and small children, patients with seizures and neurological complications, in cases of treatment failures of lindane with the need to repeat the therapy, in scabies crustosa as well as in children, pregnant woman and nursing mothers.
这项开放性临床研究旨在评估和比较林丹（1%和0.3%）、苯甲酸苄酯（20%和10%）以及氯菊酯（5%和2.5%）分别在睡前使用两次、三次和一次后，对104名成人及70名0至5岁儿童疥疮的治疗效果和副作用。使用林丹治疗后，有3名成人和2名儿童治疗失败，而经过3周随访评估，苯甲酸苄酯和氯菊酯治愈了所有患者。使用苯甲酸苄酯后，刺激和疥疮后湿疹反应的数量有所增加。氯菊酯被证明非常可靠，睡前仅使用一次时副作用很少。由于林丹存在经皮吸收和神经毒性风险，对于早产儿、幼儿、癫痫和神经系统并发症患者、林丹治疗失败需要重复治疗的情况、结痂性疥疮以及儿童、孕妇和哺乳期母亲，推荐使用氯菊酯作为一种有效的替代方法。
