Schultz M W, Gomez M, Hansen R C, Mills J, Menter A, Rodgers H, Judson F N, Mertz G, Handsfield H H
Burroughs Wellcome Co. Research, Triangle Park, NC.
Arch Dermatol. 1990 Feb;126(2):167-70.
A multicenter, randomized, investigator-blind controlled trial was conducted to compare the safety and efficacy of a single, whole-body application of 5% permethrin cream with that of 1% lindane lotion for the treatment of scabies in 467 patients. At 14 +/- 3 days after treatment, the mean active lesion count decreased from pretreatment levels of 85 (range, 4 to 600) in both treatment groups to 14 (range, 0 to 133) in the permethrin group and to 15 lesions (range, 0 to 500) in the lindane group. At 28 +/- 7 days after treatment, complete resolution had occurred in 181 (91%) of 199 patients treated with permethrin and in 176 (86%) of 205 patients given lindane. Pruritus due to scabies persisted at 28 +/- 7 days in 14% of the permethrin group and in 25% of the lindane group. The most frequent adverse effects were new or increased pruritus and mild, transient burning or stinging; the latter was slightly more frequent following permethrin treatment and appeared to be related to severity of infestation. Because of a lower potential for neurologic toxicity, permethrin may be preferable to lindane for the treatment of scabies particularly in children.
进行了一项多中心、随机、研究者盲法对照试验，以比较467例疥疮患者单次全身应用5%氯菊酯乳膏与1%林丹洗剂的安全性和疗效。治疗后14±3天，两个治疗组的平均活动性皮损计数均从治疗前的85（范围4至600）降至氯菊酯组的14（范围0至133）和林丹组的15处皮损（范围0至500）。治疗后28±7天，199例接受氯菊酯治疗的患者中有181例（91%）完全治愈，205例接受林丹治疗的患者中有176例（86%）完全治愈。氯菊酯组14%的患者和林丹组25%的患者在治疗后28±7天仍有疥疮引起的瘙痒。最常见的不良反应是新发或加重的瘙痒以及轻度、短暂的烧灼感或刺痛感；后者在氯菊酯治疗后稍常见，且似乎与感染严重程度有关。由于神经毒性的可能性较低，氯菊酯在治疗疥疮时可能比林丹更可取，尤其是在儿童中。
