白细胞介素1受体拮抗剂（IL1RN）的外显子多态性（rs315952，Ser133Ser）与超重/肥胖伴高血压有关。
Exonic polymorphism (rs315952, Ser133Ser) of interleukin 1 receptor antagonist (IL1RN) is related to overweigh/obese with hypertension.
作者信息
Yang Seung-Ae
机构信息
College of Nursing, Sungshin Women's University, Seoul, Korea.
出版信息
J Exerc Rehabil. 2014 Oct 31;10(5):332-6. doi: 10.12965/jer.140155. eCollection 2014 Oct.
Recent studies demonstrated that interleukin 1 receptor antagonist (IL-1RN) plays an important role in metabolic effects. To investigate whether IL1RN polymorphisms are associated with obesity, two single nucleotide polymorphisms (SNPs) of the IL1RN gene [rs4251961 (-828, T> C) and rs315952 (Ser133Ser)] were analyzed in 122 overweigh/obese and 123 control subjects. Overweigh/obese subjects were classified according to body mass index (BMI). SNPStats was used to obtain odds ratios (ORs), 95% confidence intervals (CIs), and P values. Multiple logistic regression models (codominant1, codominant2, dominant, recessive, and log-additive) were conducted to analyze the genetic data. Synonymous SNP (rs315952) of the IL1RN gene was associated with overweigh/obese with hypertension (OR= 4.98, 95% CI= 1.74-14.19, P = 0.003 in codominant 1 model and OR= 3.98, 95% CI= 1.48-10.74, P= 0.0029 in dominant model). However, another SNP (rs4151961) did not show association with overweigh/obese or overweigh/obese with hypertension. These results suggest that exonic SNP of IL1RN (rs 315952, Ser133Ser) may be contributed to overweigh/obese with hyper-tension.
近期研究表明，白细胞介素1受体拮抗剂（IL-1RN）在代谢效应中发挥重要作用。为了研究IL1RN基因多态性是否与肥胖相关，我们在122名超重/肥胖受试者和123名对照受试者中分析了IL1RN基因的两个单核苷酸多态性（SNP）[rs4251961（-828，T>C）和rs315952（Ser133Ser）]。超重/肥胖受试者根据体重指数（BMI）进行分类。使用SNPStats获得比值比（OR）、95%置信区间（CI）和P值。采用多个逻辑回归模型（共显性1、共显性2、显性、隐性和对数加性模型）对遗传数据进行分析。IL1RN基因的同义SNP（rs315952）与超重/肥胖合并高血压相关（共显性1模型中OR=4.98，95%CI=1.74-14.19，P=0.003；显性模型中OR=3.98，95%CI=1.48-10.74，P=0.0029）。然而，另一个SNP（rs4151961）与超重/肥胖或超重/肥胖合并高血压无关。这些结果表明，IL1RN的外显子SNP（rs 315952，Ser133Ser）可能与超重/肥胖合并高血压有关。
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