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拥挤应激对年轻雌性大鼠血压和血管功能的基因型相关影响。

Genotype-related effect of crowding stress on blood pressure and vascular function in young female rats.

机构信息

Institute of Normal and Pathological Physiology, Centre of Excellence for Examination of Regulatory Role of Nitric Oxide in Civilization Diseases, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovakia.

出版信息

Biomed Res Int. 2014;2014:413629. doi: 10.1155/2014/413629. Epub 2014 Mar 5.

DOI:10.1155/2014/413629
PMID:24729972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3963217/
Abstract

This study investigated the influence of chronic crowding stress on nitric oxide (NO) production, vascular function and oxidative status in young Wistar-Kyoto (WKY), borderline hypertensive (BHR) and spontaneously hypertensive (SHR) female rats. Five-week old rats were exposed to crowding for two weeks. Crowding elevated plasma corticosterone (P<0.05) and accelerated BP (P<0.01 versus basal) only in BHR. NO production and superoxide concentration were significantly higher in the aortas of control BHR and SHR versus WKY. Total acetylcholine (ACh)-induced relaxation in the femoral artery was reduced in control SHR versus WKY and BHR, and stress did not affect it significantly in any genotype. The attenuation of ACh-induced relaxation in SHR versus WKY was associated with reduction of its NO-independent component. Crowding elevated NO production in all strains investigated but superoxide concentration was increased only in WKY, which resulted in reduced NO-dependent relaxation in WKY. In crowded BHR and SHR, superoxide concentration was either unchanged or reduced, respectively, but NO-dependent relaxation was unchanged in both BHR and SHR versus their respective control group. This study points to genotype-related differences in stress vulnerability in young female rats. The most pronounced negative influence of stress was observed in BHR despite preserved endothelial function.

摘要

本研究探讨了慢性拥挤应激对年轻 Wistar-Kyoto（WKY）、边缘性高血压（BHR）和自发性高血压（SHR）雌性大鼠一氧化氮（NO）产生、血管功能和氧化状态的影响。五周龄大鼠接受拥挤应激两周。拥挤应激仅在 BHR 中升高血浆皮质酮（P<0.05）并加速血压（P<0.01 与基础值相比）。与 WKY 相比，对照组 BHR 和 SHR 的主动脉中 NO 产生和超氧阴离子浓度显著升高。与 WKY 和 BHR 相比，对照组 SHR 的股动脉中乙酰胆碱（ACh）诱导的松弛显著降低，应激对任何基因型均无显著影响。与 WKY 相比，SHR 中 ACh 诱导的松弛减弱与 NO 非依赖性成分减少有关。所有研究的菌株中，拥挤应激均增加了 NO 产生，但仅在 WKY 中增加了超氧阴离子浓度，导致 WKY 中依赖 NO 的松弛减少。在拥挤的 BHR 和 SHR 中，超氧阴离子浓度分别不变或降低，但 BHR 和 SHR 与各自对照组相比，NO 依赖性松弛不变。本研究指出了年轻雌性大鼠应激易感性的基因型相关差异。尽管内皮功能正常，但在 BHR 中观察到应激的最显著负面影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/de4f30452135/BMRI2014-413629.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/2be9d5d60b31/BMRI2014-413629.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/354be6d903ce/BMRI2014-413629.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/26e540d7d289/BMRI2014-413629.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/de4f30452135/BMRI2014-413629.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/2be9d5d60b31/BMRI2014-413629.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/354be6d903ce/BMRI2014-413629.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/26e540d7d289/BMRI2014-413629.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9069/3963217/de4f30452135/BMRI2014-413629.004.jpg

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