Veronese Nicola, Sergi Giuseppe, De Rui Marina, Bolzetta Francesco, Toffanello Elena Debora, Zambon Sabina, Corti Maria-Chiara, Sartori Leonardo, Musacchio Estella, Baggio Giovannella, Crepaldi Gaetano, Perissinotto Egle, Manzato Enzo
Department of Medicine (N.V., G.S., M.D.R., F.B., E.D.T., E.M.), Geriatrics Division; Department of Medical and Surgical Sciences (S.Z., E.M.); and Department of Cardiac, Thoracic, and Vascular Sciences (E.P.), Unit of Biostatistics, Epidemiology, and Public Health, University of Padova, 35128 Padova, Italy; National Research Council (S.Z., G.C., E.M.), Aging Branch, Institute of Neuroscience, 35128 Padova, Italy; Azienda Unità Locale Socio Sanitaria 16, 35127 Padova (M.-C.C.), Padova, Italy; and Internal Medicine Division (G.B.), Azienda Ospedaliera, 35128 Padova, Italy.
J Clin Endocrinol Metab. 2014 Jul;99(7):2351-8. doi: 10.1210/jc.2013-3883. Epub 2014 Apr 14.
Increasing research has shown that low levels of serum 25-hydroxyvitamin (25OHD) predict the onset of diabetes, but no research is available on this issue in elderly people.
Our objective was to examine whether low serum levels of 25OHD are associated with a higher risk of incident type 2 diabetes over a lengthy follow-up in a representative group of elderly people.
This was a population-based cohort study as part of the Progetto Veneto Anziani (Pro.V.A.) Study over a follow-up of 4.4 years in the general community.
PARTICIPANTS included 2227 participants (1728 with follow-up visits and 499 died during the follow-up) over 65 years of age without diabetes at baseline, of 2352 initially included.
The main outcome measure was incident diabetes.
There were no baseline differences in known factors for the onset of diabetes (body mass index, waist circumference, total cholesterol, renal function, and hemoglobin A1c levels) between the groups with different serum 25OHD levels (≤ 25, 25-50, 50-75, and ≥ 75 nmol/L). Over a 4.4-year follow-up, 291 individuals developed diabetes, with an incidence of 28 events per 1000 person-years. No significant difference in the incidence of diabetes emerged between the baseline 25OHD groups. Cox's regression analysis, adjusted for potential confounders, revealed no relationship between low vitamin D levels and incident diabetes during the follow-up (hazard ratio [HR] = 1.05, 95% confidence interval [CI] = 0.76-1.45, P = .77; HR = 1.44, 95% CI = 0.95-1.98, P = .12; and HR = 1.37, 95% CI = 0.87-2.16, P = .17 for those with 25OHD ≤25, 25-50, and 50-75 nmol/L, respectively).
Baseline serum concentrations of 25OHD were not associated with the incidence of diabetes in community-dwelling elderly people over a follow-up of 4.4 years.
越来越多的研究表明，血清25-羟基维生素（25OHD）水平低预示着糖尿病的发病，但尚无关于老年人这一问题的研究。
我们的目的是在一组具有代表性的老年人中进行长期随访，以研究低血清25OHD水平是否与2型糖尿病发病风险较高相关。
这是一项基于人群的队列研究，是威尼托老年人项目（Pro.V.A.）研究的一部分，在普通社区进行了4.4年的随访。
参与者包括2352名最初纳入研究的65岁以上基线时无糖尿病的人群，其中2227人（1728人接受了随访，499人在随访期间死亡）。
主要结局指标是糖尿病发病。
不同血清25OHD水平组（≤25、25 - 50、50 - 75和≥75 nmol/L）之间，糖尿病发病的已知因素（体重指数、腰围、总胆固醇、肾功能和糖化血红蛋白水平）在基线时无差异。在4.4年的随访中，291人患糖尿病，发病率为每1000人年28例。基线25OHD组之间糖尿病发病率无显著差异。经潜在混杂因素调整后的Cox回归分析显示，随访期间低维生素D水平与糖尿病发病之间无关联（25OHD≤25、25 - 50和50 - 75 nmol/L者的风险比[HR]分别为1.05，95%置信区间[CI]=0.76 - 1.45，P = 0.77；HR = 1.44，95% CI = 0.95 - 1.98，P = 0.12；HR = 1.37，95% CI = 0.87 - 2.16，P = 0.17）。
在4.4年的随访中，社区居住老年人的基线血清25OHD浓度与糖尿病发病率无关。
