• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在中国，维生素D和碘的状态与2型糖尿病的风险及并发症相关。

Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China.

作者信息

Zhuo Yafen, Ling Lin, Sun Zhichun, Huang Wensen, Hong Zhenzhen, Zhang Yaping, Peng Xuefeng, Liu Xiaoyu, Yuan Weilan, Xu Wang-Yang, Zhang Yi

机构信息

Department of Endocrinology, Quanzhou First Hospital Affiliated to Fujian Medical University, No. 250, East Street, Licheng District, Quanzhou, 362300, Fujian, China.

Department of Internal Medicine, Quanzhou Medical College, Quanzhou, 362300, China.

出版信息

Open Life Sci. 2021 Feb 18;16(1):150-159. doi: 10.1515/biol-2021-0019. eCollection 2021.

DOI:10.1515/biol-2021-0019
PMID:33817307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7968538/
Abstract

The purpose of this study was to assess the relationship between 25-hydroxyvitamin D (25(OH)D), urinary iodine concentration (UIC), and type 2 diabetes mellitus (T2DM) risk and complications and to establish a model to predict T2DM in the general population. A total of 567 adults (389 T2DM patients and 178 controls) were enrolled, and the levels of 25(OH)D, iodine, and blood biochemical parameters were measured. Pearson's correlation analysis showed an inverse correlation between 25(OH)D level, UIC, and T2DM risk. Low 25(OH)D level was a risk factor for developing T2DM (OR, 0.81; 95% CI, 1.90-2.63; = 0.043) after adjustment for multiple risk factors. 25(OH)D level and UIC were inversely correlated with short-term and long-term glucose levels. 25(OH)D deficiency was also associated with a high incidence of T2DM complicated with thyroid dysfunction. A prediction model based on 25(OH)D, iodine status, and other risk factors was established and recommended to screen high-risk T2DM in the general population and provide early screening and timely treatment for them.

摘要

本研究的目的是评估25-羟基维生素D（25(OH)D）、尿碘浓度（UIC）与2型糖尿病（T2DM）风险及并发症之间的关系，并建立一个预测普通人群中T2DM的模型。共纳入567名成年人（389例T2DM患者和178名对照），并测量了25(OH)D、碘和血液生化参数水平。Pearson相关性分析显示25(OH)D水平、UIC与T2DM风险呈负相关。在调整多个风险因素后，低25(OH)D水平是发生T2DM的一个风险因素（OR，0.81；95%CI，1.90 - 2.63； = 0.043）。25(OH)D水平和UIC与短期和长期血糖水平呈负相关。25(OH)D缺乏还与T2DM合并甲状腺功能障碍的高发生率相关。建立了一个基于25(OH)D、碘状态和其他风险因素的预测模型，并推荐用于筛查普通人群中的高危T2DM患者，并为他们提供早期筛查和及时治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/7968538/eb3ca2742355/j_biol-2021-0019-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/7968538/3ad8c3624df1/j_biol-2021-0019-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/7968538/3e7cae3a2f67/j_biol-2021-0019-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/7968538/eb3ca2742355/j_biol-2021-0019-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/7968538/3ad8c3624df1/j_biol-2021-0019-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/7968538/3e7cae3a2f67/j_biol-2021-0019-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8856/7968538/eb3ca2742355/j_biol-2021-0019-fig003.jpg

相似文献

1
Vitamin D and iodine status was associated with the risk and complication of type 2 diabetes mellitus in China.在中国，维生素D和碘的状态与2型糖尿病的风险及并发症相关。
Open Life Sci. 2021 Feb 18;16(1):150-159. doi: 10.1515/biol-2021-0019. eCollection 2021.
2
The Relationship between Vitamin D and Type 2 Diabetes Is Intriguing: Glimpses from the Spect-China Study.维生素 D 与 2 型糖尿病之间的关系耐人寻味：来自 Spect-China 研究的初步观察。
Ann Nutr Metab. 2017;71(3-4):195-202. doi: 10.1159/000480711. Epub 2017 Oct 13.
3
Correlation Analysis between Serum Vitamin D Levels and Lower Extremity Macrovascular Complications in Individuals with Type 2 Diabetes Mellitus.血清维生素 D 水平与 2 型糖尿病患者下肢大血管并发症的相关性分析。
J Diabetes Res. 2019 Nov 28;2019:4251829. doi: 10.1155/2019/4251829. eCollection 2019.
4
Vitamin D status and oxidative stress markers in the elderly with impaired fasting glucose and type 2 diabetes mellitus.空腹血糖受损及 2 型糖尿病老年患者的维生素 D 状态和氧化应激标志物。
Aging Clin Exp Res. 2012 Dec;24(6):595-602. doi: 10.3275/8591. Epub 2012 Sep 10.
5
Insufficient renal 1-alpha hydroxylase and bone homeostasis in aged rats with insulin resistance or type 2 diabetes mellitus.胰岛素抵抗或2型糖尿病老年大鼠的肾脏1-α羟化酶不足与骨稳态
J Bone Miner Metab. 2008;26(6):561-8. doi: 10.1007/s00774-008-0867-z. Epub 2008 Nov 1.
6
Serum vitamin d status and its relationship to metabolic parameters in patients with type 2 diabetes mellitus.2型糖尿病患者的血清维生素D状态及其与代谢参数的关系。
Chonnam Med J. 2012 Aug;48(2):108-15. doi: 10.4068/cmj.2012.48.2.108. Epub 2012 Aug 24.
7
25-Hydroxyvitamin D Status and Risk for Colorectal Cancer and Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Epidemiological Studies.25-羟维生素D状态与结直肠癌和2型糖尿病风险：流行病学研究的系统评价和荟萃分析
Int J Environ Res Public Health. 2017 Jan 28;14(2):127. doi: 10.3390/ijerph14020127.
8
The relationship between renal injury and change in vitamin D metabolism in aged rats with insulin resistance or type 2 diabetes mellitus.胰岛素抵抗或2型糖尿病老年大鼠肾损伤与维生素D代谢变化的关系。
J Int Med Res. 2008 Mar-Apr;36(2):289-95. doi: 10.1177/147323000803600211.
9
Relationship between vitamin D status and vascular complications in patients with type 2 diabetes mellitus.2型糖尿病患者维生素D状态与血管并发症之间的关系。
Nutr Res. 2016 Feb;36(2):117-24. doi: 10.1016/j.nutres.2015.11.008. Epub 2015 Nov 17.
10
Hypovitaminosis D is associated with erectile dysfunction in type 2 diabetes.维生素D缺乏与2型糖尿病患者的勃起功能障碍有关。
Endocrine. 2016 Sep;53(3):831-8. doi: 10.1007/s12020-015-0851-z. Epub 2016 Jan 12.

引用本文的文献

1
Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes.2型糖尿病患者碘盐摄入量与身体虚弱风险的关联。
J Nutr Health Aging. 2025 Jun;29(6):100543. doi: 10.1016/j.jnha.2025.100543. Epub 2025 Mar 25.
2
Excess Iodine Consumption Induces Oxidative Stress and Pancreatic Damage Independently of Chemical Form in Male Wistar Rats: Participation of PPAR-γ and C/EBP-β.过量碘摄入在雄性Wistar大鼠中独立于化学形式诱导氧化应激和胰腺损伤：PPAR-γ和C/EBP-β的参与
Biology (Basel). 2024 Jun 25;13(7):466. doi: 10.3390/biology13070466.
3
Does Iodine Influence the Metabolism of Glucose?

本文引用的文献

1
The prevalence of vitamin D deficiency among patients with type 2 diabetes seen at a referral hospital in Kenya.肯尼亚一家转诊医院中2型糖尿病患者维生素D缺乏症的患病率。
Pan Afr Med J. 2019 Sep 17;34:38. doi: 10.11604/pamj.2019.34.38.18936. eCollection 2019.
2
Obesity And Diabetes As Determinants Of Vitamin D Deficiency.肥胖与糖尿病作为维生素D缺乏的决定因素
J Ayub Med Coll Abbottabad. 2019 Jul-Sep;31(3):432-435.
3
Vitamin D suppresses cellular pathways of diabetes complication in liver.维生素D可抑制肝脏中糖尿病并发症的细胞信号通路。
碘会影响葡萄糖的代谢吗？
Medicina (Kaunas). 2023 Jan 17;59(2):189. doi: 10.3390/medicina59020189.
4
Vitamin D and the Thyroid: A Critical Review of the Current Evidence.维生素 D 与甲状腺：当前证据的批判性回顾。
Int J Mol Sci. 2023 Feb 10;24(4):3586. doi: 10.3390/ijms24043586.
Iran J Basic Med Sci. 2019 Jun;22(6):690-694. doi: 10.22038/ijbms.2019.36054.8584.
4
Association of vitamin D deficiency with insulin resistance in middle-aged type 2 diabetics.维生素 D 缺乏与中年 2 型糖尿病患者胰岛素抵抗的相关性。
Clin Chim Acta. 2019 May;492:95-101. doi: 10.1016/j.cca.2019.02.014. Epub 2019 Feb 14.
5
Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders.甲状腺功能紊乱与糖尿病：两种密切相关的疾病。
Endocr Rev. 2019 Jun 1;40(3):789-824. doi: 10.1210/er.2018-00163.
6
Effect of Vitamin D Treatment on Glucose Homeostasis and Metabolism in Lebanese Older Adults: A Randomized Controlled Trial.维生素 D 治疗对黎巴嫩老年成年人葡萄糖稳态和代谢的影响：一项随机对照试验。
J Nutr Health Aging. 2018;22(9):1128-1132. doi: 10.1007/s12603-018-1083-8.
7
Vitamin D levels are associated with metabolic syndrome in adolescents and young adults: The BCAMS study.维生素 D 水平与青少年和年轻成年人代谢综合征有关：BCAMS 研究。
Clin Nutr. 2019 Oct;38(5):2161-2167. doi: 10.1016/j.clnu.2018.08.039. Epub 2018 Sep 6.
8
1,25-Dihydroxyvitamin D enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.1,25-二羟维生素 D 增强了小鼠和人胰岛中葡萄糖刺激的胰岛素分泌：维生素 D 受体对电压门控钙通道的转录调控作用。
J Steroid Biochem Mol Biol. 2019 Jan;185:17-26. doi: 10.1016/j.jsbmb.2018.07.004. Epub 2018 Jul 30.
9
Vitamin D and Incidence of Prediabetes or Type 2 Diabetes: A Four-Year Follow-Up Community-Based Study.维生素 D 与糖尿病前期或 2 型糖尿病发病风险：一项基于社区的四年随访研究。
Dis Markers. 2018 Mar 18;2018:1926308. doi: 10.1155/2018/1926308. eCollection 2018.
10
Higher serum 25(OH)D level is associated with decreased risk of impairment of glucose homeostasis: data from Southwest China.血清25(OH)D水平升高与葡萄糖稳态受损风险降低相关：来自中国西南部的数据。
BMC Endocr Disord. 2018 May 9;18(1):25. doi: 10.1186/s12902-018-0252-4.