Glasbrenner B, Malfertheiner P, Büchler M, Brändle F, Friess H, Ditschuneit H
Department of Internal Medicine and Gastroenterology, University of Ulm, FRG.
Int J Pancreatol. 1989 Jul;5(1):55-67. doi: 10.1007/BF02925698.
Pancreatic adaptation following prolonged exposition to growth promoting conditions (protease inhibitor feeding, B II subtotal gastrectomy, subtotal colectomy) was studied in rats. Fifty male Wistar rats were divided into 5 groups: controls (n = 10), sham-operated (n = 10), low dose protease inhibitor feeding (n = 10), B II subtotal gastrectomy (n = 10), and subtotal colectomy (n = 10). After 4 mo a significant increase in pancreatic wet wt and DNA content was observed in rats after protease inhibitor feeding (p less than 0.01), B II gastrectomy (p less than 0.01), and subtotal colectomy (p less than 0.05). Pancreatic total protein and lipase content were significantly increased in these three groups. Amylase and trypsin content increased after feeding the protease inhibitor (p less than 0.01) and following B II subtotal resection (p less than 0.01) but were unaffected after subtotal colectomy. Comparing the long-term effects (4 mo) with our previously published short-term data (4 wk) under the same experimental conditions, pancreatic trophism after 4 mo is less pronounced but characterized by a change in the enzyme composition with an increase in pancreatic lipase content.
在大鼠中研究了长期暴露于促生长条件（蛋白酶抑制剂喂养、毕Ⅱ式胃大部切除术、结肠次全切除术）后胰腺的适应性变化。将50只雄性Wistar大鼠分为5组：对照组（n = 10）、假手术组（n = 10）、低剂量蛋白酶抑制剂喂养组（n = 10）、毕Ⅱ式胃大部切除术组（n = 10）和结肠次全切除术组（n = 10）。4个月后，观察到蛋白酶抑制剂喂养组（p < 0.01）、毕Ⅱ式胃大部切除术组（p < 0.01）和结肠次全切除术组（p < 0.05）大鼠的胰腺湿重和DNA含量显著增加。这三组的胰腺总蛋白和脂肪酶含量均显著增加。蛋白酶抑制剂喂养后（p < 0.01）和毕Ⅱ式次全切除术后（p < 0.01）淀粉酶和胰蛋白酶含量增加，但结肠次全切除术后未受影响。将相同实验条件下的长期效应（4个月）与我们之前发表的短期数据（4周）进行比较，4个月后的胰腺营养作用不那么明显，但以酶组成变化和胰腺脂肪酶含量增加为特征。
