Büchler M, Malfertheiner P, Friess H, Eiberle E, Beger H G
Dept. of General Surgery and Gastroenterology, University Hospital, Ulm, FRG.
Scand J Gastroenterol Suppl. 1988;151:114-22. doi: 10.3109/00365528809095923.
The gastrointestinal system is substantially involved in the regulation of exocrine pancreatic secretion, and it is therefore not surprising that intestinal diseases have been shown to affect exocrine pancreatic function. In rat experiments gastrectomy, truncal vagotomy, and subtotal colectomy stimulated pancreatic growth and altered pancreatic enzyme composition. Focusing on two main hormones supposed to be involved in the regulation of pancreatic adaptation, we studied basal and stimulated gastrin and cholecystokinin (CCK) pattern after the operative procedures. After total gastrectomy basal CCK values were unchanged, whereas postprandial CCK plasma values and the integrated postprandial CCK release were significantly increased. After subtotal colectomy CCK levels, both basal and postprandial, were significantly increased. In both of these conditions gastrin levels were either decreased (total gastrectomy) or unchanged (subtotal colectomy). CCK may therefore be the major humoral candidate to promote the observed pancreatic adaptive response. After truncal vagotomy CCK values remained unchanged, whereas basal and postprandial gastrin was significantly increased. Gastrin may be a candidate involved in the stimulation of pancreatic trophism after vagisection.
胃肠系统在胰腺外分泌的调节中发挥着重要作用，因此肠道疾病会影响胰腺外分泌功能也就不足为奇了。在大鼠实验中，胃切除术、迷走神经干切断术和结肠次全切除术刺激了胰腺生长并改变了胰腺酶的组成。针对两种被认为参与胰腺适应性调节的主要激素，我们研究了手术操作后基础和刺激状态下的胃泌素和胆囊收缩素（CCK）模式。全胃切除术后，基础CCK值未发生变化，而餐后CCK血浆值和餐后CCK的综合释放量显著增加。结肠次全切除术后，基础和餐后CCK水平均显著升高。在这两种情况下，胃泌素水平要么降低（全胃切除术），要么未发生变化（结肠次全切除术）。因此，CCK可能是促进观察到的胰腺适应性反应的主要体液因子。迷走神经干切断术后CCK值保持不变，而基础和餐后胃泌素水平显著升高。胃泌素可能是参与迷走神经切断术后胰腺营养刺激的一个因素。
