Watson Emma, Walhout Albertha J M
Program in Systems Biology, Program in Molecular Medicine, University of Massachusetts Medical School, 55 North Lake Ave, Worcester, MA, 01655, USA.
Program in Systems Biology, Program in Molecular Medicine, University of Massachusetts Medical School, 55 North Lake Ave, Worcester, MA, 01655, USA.
Trends Endocrinol Metab. 2014 Oct;25(10):502-8. doi: 10.1016/j.tem.2014.03.004. Epub 2014 Apr 12.
Diet greatly impacts metabolism in health and disease. In response to the presence or absence of specific nutrients, metabolic gene regulatory networks sense the metabolic state of the cell and regulate metabolic flux accordingly, for instance by the transcriptional control of metabolic enzymes. Here, we discuss recent insights regarding metazoan metabolic regulatory networks using the nematode Caenorhabditis elegans as a model, including the modular organization of metabolic gene regulatory networks, the prominent impact of diet on the transcriptome and metabolome, specialized roles of nuclear hormone receptors (NHRs) in responding to dietary conditions, regulation of metabolic genes and metabolic regulators by miRNAs, and feedback between metabolic genes and their regulators.
饮食对健康和疾病状态下的新陈代谢有重大影响。针对特定营养素的存在或缺失，代谢基因调控网络会感知细胞的代谢状态，并相应地调节代谢通量，例如通过对代谢酶的转录控制来实现。在此，我们以线虫秀丽隐杆线虫为模型，讨论后生动物代谢调控网络的最新见解，包括代谢基因调控网络的模块化组织、饮食对转录组和代谢组的显著影响、核激素受体（NHRs）在应对饮食条件中的特殊作用、miRNA对代谢基因和代谢调节因子的调控，以及代谢基因与其调节因子之间的反馈。
