牙囊和发育性囊肿中牙源性上皮的细胞角蛋白表达
Cytokeratin expression of the odontogenic epithelia in dental follicles and developmental cysts.
作者信息
Gao Z, Mackenzie I C, Cruchley A T, Williams D M, Leigh I, Lane E B
机构信息
Dows Institute for Dental Research, University of Iowa.
出版信息
J Oral Pathol Med. 1989 Feb;18(2):63-7. doi: 10.1111/j.1600-0714.1989.tb00738.x.
The patterns of cytokeratin expression in the epithelium of 5 dental follicles, 7 dentigerous cysts, 5 odontogenic keratocysts, 3 nasopalatine cysts and an epidermoid cyst have been studies using a panel of monoclonal antibodies. The epithelium of dental follicles and of developmental odontogenic cysts strongly expressed keratins 5 and 19 and showed weaker expression of keratins typical of stratified non-cornified and of simple epithelia. Staining with mAbs against the latter keratins varied with the degree of epithelial differentiation. Nasopalatine cysts strongly expressed simple epithelial keratins and the epidermoid cyst strongly expressed a marker of cornification. Odontogenic cysts thus appear to differ in their pattern of keratin expression from other oral developmental cysts and all derivatives of odontogenic epithelia appear to share similar basic patterns of cytokeratin expression.
使用一组单克隆抗体研究了5个牙囊、7个含牙囊肿、5个牙源性角化囊肿、3个鼻腭囊肿和1个表皮样囊肿上皮中的细胞角蛋白表达模式。牙囊和发育性牙源性囊肿的上皮强烈表达角蛋白5和19，而分层非角化和单层上皮典型的角蛋白表达较弱。针对后一种角蛋白的单克隆抗体染色随上皮分化程度而异。鼻腭囊肿强烈表达单层上皮角蛋白，表皮样囊肿强烈表达角化标记物。因此，牙源性囊肿在角蛋白表达模式上似乎与其他口腔发育性囊肿不同，并且牙源性上皮的所有衍生物似乎都具有相似的细胞角蛋白表达基本模式。
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