内皮素-1对体内小动脉和小静脉的作用。
Effect of endothelin-1 on arterioles and venules in vivo.
作者信息
Fortes Z B, de Nucci G, Garcia-Leme J
机构信息
Department of Pharmacology, University of São Paulo, Brazil.
出版信息
J Cardiovasc Pharmacol. 1989;13 Suppl 5:S200-1. doi: 10.1097/00005344-198900135-00056.
The vasoconstrictor effects of endothelin-1 (ET-1) and norepinephrine (NE) were compared in the exteriorized rat mesentery in situ. ET-1 was 1,000 times more potent than NE in constricting both arterioles and venules. Vasoconstrictions induced by ET-1 lasted much longer than those caused by the catecholamine. At nonrelaxant doses, acetylcholine and sodium nitroprusside antagonized the constrictive response of microvessels to ET-1 and NE. However, larger doses of acetylcholine were necessary to inhibit the response to ET-1 than that to NE.
在原位暴露的大鼠肠系膜中比较了内皮素-1（ET-1）和去甲肾上腺素（NE）的血管收缩作用。在收缩小动脉和小静脉方面，ET-1的效力比NE强1000倍。ET-1诱导的血管收缩持续时间比儿茶酚胺引起的长得多。在非松弛剂量下，乙酰胆碱和硝普钠可拮抗微血管对ET-1和NE的收缩反应。然而，抑制对ET-1的反应比抑制对NE的反应需要更大剂量的乙酰胆碱。
Zotero 插件