Lin Feng, Roiland Rachel, Chen Ding-Geng Din, Qiu Christina
School of Nursing, University of Rochester, Rochester, NY, USA; Department of Psychiatry, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Int J Geriatr Psychiatry. 2015 Jan;30(1):64-71. doi: 10.1002/gps.4115. Epub 2014 Apr 15.
This study examined whether metabolic syndrome (MetS) would moderate the association of cognition with frailty in middle and old age.
A cross-sectional design was used. Six hundred and ninety participants (age ≥ 50 years) from an on-going national survey were included in the study. Confirmatory factor analysis was applied to determine latent variables of executive function (EF), episodic memory (EM), and MetS based on relevant measurements. Frailty was defined using a modified form of Fried's criteria.
Applying structural equation modeling, having MetS significantly increased the likelihood of being frail. Better performance on EM tasks, but not EF, was significantly associated with lower likelihood of MetS. Worse performance on EF, but not EM, significantly increased the likelihood of being frail. There was a significant interacting effect between MetS and EF, but not EM, on frailty. Further contrast analysis indicated that having MetS strengthened the negative association between EF and frailty.
Metabolic syndrome moderates the relationship between EF and frailty. A prospecitve study is needed to validate such relationships before developing interventions targeting the prevention or treatment of EF and frailty in individuals with MetS.
本研究探讨代谢综合征（MetS）是否会调节中老年人群认知与衰弱之间的关联。
采用横断面设计。研究纳入了来自一项正在进行的全国性调查的690名参与者（年龄≥50岁）。基于相关测量，应用验证性因素分析来确定执行功能（EF）、情景记忆（EM）和代谢综合征的潜在变量。采用改良版弗里德标准定义衰弱。
应用结构方程模型，患有代谢综合征显著增加了衰弱的可能性。情景记忆任务表现较好（而非执行功能）与代谢综合征可能性较低显著相关。执行功能表现较差（而非情景记忆）显著增加了衰弱的可能性。代谢综合征与执行功能之间存在显著的交互作用（而非与情景记忆），对衰弱产生影响。进一步的对比分析表明，患有代谢综合征强化了执行功能与衰弱之间的负相关。
代谢综合征调节了执行功能与衰弱之间的关系。在针对患有代谢综合征个体制定预防或治疗执行功能和衰弱的干预措施之前，需要进行前瞻性研究来验证这种关系。
